Hing C Wong
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Explore the profile of Hing C Wong including associated specialties, affiliations and a list of published articles.
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65
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3540
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Recent Articles
1.
Shrestha N, Dee M, Chaturvedi P, Leclerc G, Mathyer M, Dufour C, et al.
Cancer Immunol Immunother
. 2024 Jul;
73(9):179.
PMID: 38960949
Adoptive cellular therapy (ACT) using memory-like (ML) natural killer (NK) cells, generated through overnight ex vivo activation with IL-12, IL-15, and IL-18, has shown promise for treating hematologic malignancies. We...
2.
Lim S, Lee J, Osuna C, Vikhe P, Schalk D, Chen E, et al.
Science
. 2024 Feb;
383(6687):1104-1111.
PMID: 38422185
The eradication of the viral reservoir represents the major obstacle to the development of a clinical cure for established HIV-1 infection. Here, we demonstrate that the administration of N-803 (brand...
3.
Shrestha N, Chaturvedi P, Zhu X, Dee M, George V, Janney C, et al.
Aging Cell
. 2023 Mar;
22(5):e13806.
PMID: 36967480
Accumulation of senescent cells (SNCs) with a senescence-associated secretory phenotype (SASP) has been implicated as a major source of chronic sterile inflammation leading to many age-related pathologies. Herein, we provide...
4.
Zhu X, Li Q, George V, Spanoudis C, Gilkes C, Shrestha N, et al.
Front Immunol
. 2023 Feb;
14:1114802.
PMID: 36761778
Atherosclerosis is a chronic inflammatory disease caused by deposition of oxidative low-density lipoprotein (LDL) in the arterial intima which triggers the innate immune response through myeloid cells such as macrophages....
5.
Chaturvedi P, George V, Shrestha N, Wang M, Dee M, Zhu X, et al.
Mol Ther
. 2022 Jan;
30(3):1171-1187.
PMID: 35051615
Therapy induced senescence (TIS) in tumors and TIS cancer cells secrete proinflammatory senescence-associated secretory phenotype (SASP) factors. SASP factors promote TIS cancer cells to re-enter the growth cycle with stemness...
6.
Becker-Hapak M, Shrestha N, McClain E, Dee M, Chaturvedi P, Leclerc G, et al.
Cancer Immunol Res
. 2021 Jul;
9(9):1071-1087.
PMID: 34244297
Natural killer (NK) cells are a promising cellular therapy for cancer, with challenges in the field including persistence, functional activity, and tumor recognition. Briefly, priming blood NK cells with recombinant...
7.
Liu B, Zhu X, Kong L, Wang M, Spanoudis C, Chaturvedi P, et al.
Mol Ther
. 2021 Jun;
29(10):2949-2962.
PMID: 34091051
Advances in immunostimulatory and anti-immunosuppressive therapeutics have revolutionized cancer treatment. However, novel immunotherapeutics with these dual functions are not frequently reported. Here we describe the creation of a heterodimeric bifunctional...
8.
Jochems C, Tritsch S, Knudson K, Gameiro S, Smalley Rumfield C, Pellom S, et al.
Oncoimmunology
. 2019 Feb;
8(2):e1532764.
PMID: 30713787
Here we describe a novel bifunctional fusion protein, designated N-809. This molecule comprises the IL-15/IL15Rα superagonist complex containing the Fc-domain of IgG1 (N-803, formerly designated as ALT-803) fused to two...
9.
Fantini M, David J, Wong H, Annunziata C, Arlen P, Tsang K
Cancer Biother Radiopharm
. 2019 Jan;
34(3):147-159.
PMID: 30601063
Background: A major mechanism of action for therapeutic antibodies is antibody-dependent cell-mediated cytotoxicity (ADCC). ALT-803 is an interleukin-15 superagonist complex that enhances ADCC against human carcinoma cells in vitro and...
10.
Margolin K, Morishima C, Velcheti V, Miller J, Lee S, Silk A, et al.
Clin Cancer Res
. 2018 Jul;
24(22):5552-5561.
PMID: 30045932
IL15 induces the activation and proliferation of natural killer (NK) and memory CD8 T cells and has preclinical antitumor activity. Given the superior activity and favorable kinetics of ALT-803 (IL15N72D:IL15RαSu/IgG1...