Hila Epstein-Barash
Overview
Explore the profile of Hila Epstein-Barash including associated specialties, affiliations and a list of published articles.
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11
Citations
1360
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Recent Articles
1.
Gilleron J, Querbes W, Zeigerer A, Borodovsky A, Marsico G, Schubert U, et al.
Nat Biotechnol
. 2013 Jun;
31(7):638-46.
PMID: 23792630
Delivery of short interfering RNAs (siRNAs) remains a key challenge in the development of RNA interference (RNAi) therapeutics. A better understanding of the mechanisms of siRNA cellular uptake, intracellular transport...
2.
Hobo W, Novobrantseva T, Fredrix H, Wong J, Milstein S, Epstein-Barash H, et al.
Cancer Immunol Immunother
. 2012 Aug;
62(2):285-97.
PMID: 22903385
Dendritic cell (DC)-based vaccination boosting antigen-specific immunity is being explored for the treatment of cancer and chronic viral infections. Although DC-based immunotherapy can induce immunological responses, its clinical benefit has...
3.
Kang M, Yang G, Charisse K, Epstein-Barash H, Manoharan M, Li L
J Vis Exp
. 2012 Aug;
(65).
PMID: 22872227
We present a novel method for treating bladder cancer with intravesically delivered small activating RNA (saRNA) in an orthotopic xenograft mouse bladder tumor model. The mouse model is established by...
4.
Kang M, Yang G, Place R, Charisse K, Epstein-Barash H, Manoharan M, et al.
Cancer Res
. 2012 Aug;
72(19):5069-79.
PMID: 22869584
Practical methods for enhancing protein production in vivo remain a challenge. RNA activation (RNAa) is emerging as one potential solution by using double-stranded RNA (dsRNA) to increase endogenous gene expression....
5.
Zeigerer A, Gilleron J, Bogorad R, Marsico G, Nonaka H, Seifert S, et al.
Nature
. 2012 May;
485(7399):465-70.
PMID: 22622570
An outstanding question is how cells control the number and size of membrane organelles. The small GTPase Rab5 has been proposed to be a master regulator of endosome biogenesis. Here,...
6.
Epstein-Barash H, Stefanescu C, Kohane D
Acta Biomater
. 2012 Feb;
8(5):1703-9.
PMID: 22342597
There is a clear need for methods to provide a safe controlled release of therapeutic proteins, either to achieve and maintain high local protein concentrations, or for sustained systemic delivery....
7.
Alendronate liposomes for antitumor therapy: activation of γδ T cells and inhibition of tumor growth
Gutman D, Epstein-Barash H, Tsuriel M, Golomb G
Adv Exp Med Biol
. 2011 Nov;
733:165-79.
PMID: 22101722
Circulating γδ T cells are cytotoxic lymphocytes that are unique to primates. Recent -studies have shown that amino-bisphosphonates (nBP) activate γδ T cells to kill tumor cells in an indirect...
8.
Leuschner F, Dutta P, Gorbatov R, Novobrantseva T, Donahoe J, Courties G, et al.
Nat Biotechnol
. 2011 Oct;
29(11):1005-10.
PMID: 21983520
Excessive and prolonged activity of inflammatory monocytes is a hallmark of many diseases with an inflammatory component. In such conditions, precise targeting of these cells could be therapeutically beneficial while...
9.
Epstein-Barash H, Gutman D, Markovsky E, Mishan-Eisenberg G, Koroukhov N, Szebeni J, et al.
J Control Release
. 2010 Apr;
146(2):182-95.
PMID: 20359513
Partial inactivation and transient depletion of monocytes/macrophages by liposomal bisphosphonates (LIP-BPs) is widely experimented in various inflammatory disorders including restenosis. Previous studies on activation of cytokines by LIP-BPs are limited...
10.
Epstein-Barash H, Orbey G, Polat B, Ewoldt R, Feshitan J, Langer R, et al.
Biomaterials
. 2010 Mar;
31(19):5208-17.
PMID: 20347484
Here we develop an injectable composite system based for repeated ultrasound-triggered on-demand drug delivery. An in situ-cross-linking hydrogel maintains model drug (dye)-containing liposomes in close proximity to gas-filled microbubbles that...