A Microcomposite Hydrogel for Repeated On-demand Ultrasound-triggered Drug Delivery

Overview

Journal Biomaterials

Specialty Biomedical Engineering

Date 2010 Mar 30

PMID 20347484

Citations 47

Authors

Hila Epstein-Barash

Gizem Orbey

Baris E Polat

Randy H Ewoldt

Jameel Feshitan

Robert Langer

Mark A Borden

Daniel S Kohane

Affiliations

Soon will be listed here.

Abstract

Here we develop an injectable composite system based for repeated ultrasound-triggered on-demand drug delivery. An in situ-cross-linking hydrogel maintains model drug (dye)-containing liposomes in close proximity to gas-filled microbubbles that serve to enhance release events induced by ultrasound application. Dye release is tunable by varying the proportions of the liposomal and microbubble components, as well as the duration and intensity of the ultrasound pulses in vitro. Dye is minimal at baseline. The composite shows minimal cytotoxicity in vitro, and benign tissue reaction after subcutaneous injection in rats. Ultrasound application also triggers drug release for two weeks after injection in vivo.

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