Hideo Tsubouchi
Overview
Explore the profile of Hideo Tsubouchi including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
755
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Recent Articles
1.
Palihati M, Iwasaki H, Tsubouchi H
Life Sci Alliance
. 2023 Nov;
7(2).
PMID: 38016757
The tumor suppressor plays a critical role in homologous recombination by regulating RAD51, the eukaryotic homologous recombinase. We identified the BRCA2 homolog in a Basidiomycota yeast, BRCA2 homologs are found...
2.
Lee W, Iwasaki H, Tsubouchi H, Li H
Nucleic Acids Res
. 2023 Jul;
51(16):8550-8562.
PMID: 37395447
In meiosis, Dmc1 recombinase and the general recombinase Rad51 are responsible for pairing homologous chromosomes and exchanging strands. Fission yeast (Schizosaccharomyces pombe) Swi5-Sfr1 and Hop2-Mnd1 stimulate Dmc1-driven recombination, but the...
3.
Tsubouchi H
Biomolecules
. 2023 May;
13(4).
PMID: 37189409
Homologous recombination (HR) is essential for meiosis in most sexually reproducing organisms, where it is induced upon entry into meiotic prophase. Meiotic HR is conducted by the collaborative effort of...
4.
Esquivel-Chavez A, Maki T, Tsubouchi H, Handa T, Kimura H, Haber J, et al.
Genes Genet Syst
. 2022 Jul;
97(3):123-138.
PMID: 35908934
Mating-type (P or M) of fission yeast Schizosaccharomyces pombe is determined by the transcriptionally active mat1 cassette and is switched by gene conversion using a donor, either mat2 or mat3,...
5.
Palihati M, Tsubouchi H, Argunhan B, Kajitani R, Bakenova O, Han Y, et al.
Curr Genet
. 2021 Jul;
67(6):919-936.
PMID: 34296348
Here, we report the development of methodologies that enable genetic modification of a Basidiomycota yeast, Naganishia liquifaciens. The gene targeting method employs electroporation with PCR products flanked by an 80 ...
6.
Tsubouchi H, Argunhan B, Iwasaki H
Curr Opin Genet Dev
. 2021 Jul;
71:19-26.
PMID: 34246071
Homologous recombination (HR) is a universal phenomenon conserved from viruses to humans. The mechanisms of HR are essentially the same in humans and simple unicellular eukaryotes like yeast. Two highly...
7.
Muraszko J, Kramarz K, Argunhan B, Ito K, Baranowska G, Kurokawa Y, et al.
Nucleic Acids Res
. 2021 Jun;
49(12):6832-6848.
PMID: 34157114
Rad51 is the key protein in homologous recombination that plays important roles during DNA replication and repair. Auxiliary factors regulate Rad51 activity to facilitate productive recombination, and prevent inappropriate, untimely...
8.
Argunhan B, Iwasaki H, Tsubouchi H
DNA Repair (Amst)
. 2021 Jun;
104:103114.
PMID: 34111757
DNA is the molecule that stores the chemical instructions necessary for life and its stability is therefore of the utmost importance. Despite this, DNA is damaged by both exogenous and...
9.
Zdravkovic A, Daley J, Dutta A, Niwa T, Murayama Y, Kanamaru S, et al.
Proc Natl Acad Sci U S A
. 2021 Apr;
118(11).
PMID: 33836577
The Mre11-Rad50-Nbs1 complex (MRN) is important for repairing DNA double-strand breaks (DSBs) by homologous recombination (HR). The endonuclease activity of MRN is critical for resecting 5'-ended DNA strands at DSB...
10.
Afshar N, Argunhan B, Palihati M, Taniguchi G, Tsubouchi H, Iwasaki H
Elife
. 2021 Jan;
10.
PMID: 33493431
Homologous recombination (HR) is essential for maintaining genome stability. Although Rad51 is the key protein that drives HR, multiple auxiliary factors interact with Rad51 to potentiate its activity. Here, we...