Hidehiko Kumagai
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Explore the profile of Hidehiko Kumagai including associated specialties, affiliations and a list of published articles.
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85
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2301
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Recent Articles
1.
Matsuzaki C, Hidaka M, Nakashima Y, Honda Y, Koyanagi T, Ishikawa K, et al.
Proc Jpn Acad Ser B Phys Biol Sci
. 2025 Feb;
101(3):177-195.
PMID: 39971319
Enhancing the thermostability of cellulose-degrading enzymes is pivotal for establishing an efficient bioconversion system from cellulosic materials to value-added compounds. Here, by introducing random and saturation mutagenesis into the Thermoascus...
2.
Kumagai H, Katayama T, Koyanagi T, Suzuki H
Proc Jpn Acad Ser B Phys Biol Sci
. 2023 Mar;
99(3):75-101.
PMID: 36908174
L-DOPA is an amino acid that is used as a treatment for Parkinson's disease. A simple enzymatic synthesis method of L-DOPA had been developed using bacterial L-tyrosine phenol-lyase (Tpl). This...
3.
Suzuki H, Fukuyama K, Kumagai H
Proc Jpn Acad Ser B Phys Biol Sci
. 2020 Nov;
96(9):440-469.
PMID: 33177298
γ-Glutamyltranspeptidase (GGT) has been widely used as a marker enzyme of hepatic and biliary diseases and relations between various diseases and its activity have been studied extensively. Nevertheless, several of...
4.
Matsumura E, Nakagawa A, Tomabechi Y, Ikushiro S, Sakaki T, Katayama T, et al.
Sci Rep
. 2018 May;
8(1):7980.
PMID: 29789647
Natural products from plants are useful as lead compounds in drug discovery. Plant benzylisoquinoline alkaloids (BIAs) exhibit various pharmaceutical activities. Although unidentified BIAs are expected to be of medicinal value,...
5.
Barla F, Koyanagi T, Tokuda N, Matsui H, Katayama T, Kumagai H, et al.
Biotechnol Rep (Amst)
. 2017 Mar;
10:105-110.
PMID: 28352530
Many traditional fermented products are onsumed in Ishikawa Prefecture, Japan, such as , , , and Various kinds of lactic acid bacteria (LAB) are associated with their fermentation, however, characterization...
6.
Matsumura E, Nakagawa A, Tomabechi Y, Koyanagi T, Kumagai H, Yamamoto K, et al.
Biosci Biotechnol Biochem
. 2016 Oct;
81(2):396-402.
PMID: 27740901
Benzylisoquinoline alkaloids (BIAs) are a group of plant secondary metabolites that have been identified as targets for drug discovery because of their diverse pharmaceutical activities. Well-known BIAs are relatively abundant...
7.
Sugiyama Y, Gotoh A, Katoh T, Honda Y, Yoshida E, Kurihara S, et al.
Glycobiology
. 2016 Aug;
26(11):1235-1247.
PMID: 27550195
Fucα1-2 Gal linkages, or H-antigens, constitute histo-blood group antigens and are involved in various physiological processes. In addition, recent studies have shown that the H-antigen-containing glycans play an important role,...
8.
Nakagawa A, Matsumura E, Koyanagi T, Katayama T, Kawano N, Yoshimatsu K, et al.
Nat Commun
. 2016 Feb;
7:10390.
PMID: 26847395
Opiates such as morphine and codeine are mainly obtained by extraction from opium poppies. Fermentative opiate production in microbes has also been investigated, and complete biosynthesis of opiates from a...
9.
Koyanagi T, Nakagawa A, Kiyohara M, Matsui H, Tsuji A, Barla F, et al.
Biosci Biotechnol Biochem
. 2015 Oct;
80(2):399-406.
PMID: 26479869
Sake is made from steamed rice, malted rice, and water. Sake production begins with the preparation of a small-scale starter (moto); the quality of moto significantly influences the flavor and...
10.
Nakagawa A, Matsuzaki C, Matsumura E, Koyanagi T, Katayama T, Yamamoto K, et al.
Sci Rep
. 2014 Oct;
4:6695.
PMID: 25331563
Tetrahydropapaveroline (THP), a benzylisoquinoline alkaloid (BIA) found in diverse pharmaceutical compounds, is used as a starting material for the production of BIA. THP also has various neurobiological properties but is...