Hideaki Tsuge
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Explore the profile of Hideaki Tsuge including associated specialties, affiliations and a list of published articles.
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Articles
66
Citations
786
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Recent Articles
1.
Tsuge H, Habuka N, Yoshida T
Toxins (Basel)
. 2024 Jul;
16(7).
PMID: 39057953
ADP-ribosylation is a ubiquitous modification of proteins and other targets, such as nucleic acids, that regulates various cellular functions in all kingdoms of life. Furthermore, these ADP-ribosyltransferases (ARTs) modify a...
2.
Falke S, Lieske J, Herrmann A, Loboda J, Karnicar K, Gunther S, et al.
J Med Chem
. 2024 Apr;
67(9):7048-7067.
PMID: 38630165
Emerging RNA viruses, including SARS-CoV-2, continue to be a major threat. Cell entry of SARS-CoV-2 particles via the endosomal pathway involves cysteine cathepsins. Due to ubiquitous expression, cathepsin L (CatL)...
3.
Kawamoto A, Yamada T, Yoshida T, Sato Y, Kato T, Tsuge H
Nat Commun
. 2022 Oct;
13(1):6119.
PMID: 36253419
Some bacteria express a binary toxin translocation system, consisting of an enzymatic subunit and translocation pore, that delivers enzymes into host cells through endocytosis. The most clinically important bacterium with...
4.
Yamada T, Tsuge H
Methods Enzymol
. 2021 Mar;
649:125-148.
PMID: 33712185
Iota toxin, a type of A-B toxin produced by Clostridium perfringens, comprises an enzymatic component (Ia) and a membrane-binding component (Ib). The translocation of Ia to the target cell via...
5.
Yoshida T, Tsuge H
Toxins (Basel)
. 2021 Jan;
13(1).
PMID: 33430384
Many bacterial pathogens utilize ADP-ribosyltransferases (ARTs) as virulence factors. The critical aspect of ARTs is their target specificity. Each individual ART modifies a specific residue of its substrates, which could...
6.
Tsuge H
J Biol Chem
. 2020 Jun;
295(26):8706-8707.
PMID: 32591442
The formation of a mature, multilayered myelin sheath requires the compaction of lipid bilayers, but the molecular mechanism by which these bilayers condense is an open question. In this issue,...
7.
Yamada T, Yoshida T, Kawamoto A, Mitsuoka K, Iwasaki K, Tsuge H
Nat Struct Mol Biol
. 2020 Mar;
27(3):288-296.
PMID: 32123390
The iota toxin produced by Clostridium perfringens type E is a binary toxin comprising two independent polypeptides: Ia, an ADP-ribosyltransferase, and Ib, which is involved in cell binding and translocation...
8.
Yoshida T, Tsuge H
J Biol Chem
. 2018 Aug;
293(36):13768-13774.
PMID: 30072382
ScARP from the bacterium belongs to the pierisin family of DNA-targeting ADP-ribosyltransferases (ARTs). These enzymes ADP-ribosylate the N amino groups of guanine residues in DNA to yield N-(ADP-ribos-1-yl)-2'-deoxyguanosine. Although the...
9.
Kobayashi H, Otsubo T, Teraoka F, Ikeda K, Seike S, Takahashi E, et al.
PLoS One
. 2017 Oct;
12(10):e0186392.
PMID: 29023605
Aeromonas sobria serine protease (ASP) is an extracellular serine protease secreted by the organism. Here, we identified the amino acid residue of ASP that contributes to substrate specificity by using...
10.
Toniti W, Yoshida T, Tsurumura T, Irikura D, Monma C, Kamata Y, et al.
PLoS One
. 2017 Feb;
12(2):e0171278.
PMID: 28199340
Unusual outbreaks of food poisoning in Japan were reported in which Clostridium perfringens was strongly suspected to be the cause based on epidemiological information and fingerprinting of isolates. The isolated...