Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases

Overview

Journal Toxins (Basel)

Publisher MDPI

Specialty Toxicology

Date 2021 Jan 12

PMID 33430384

Citations 7

Authors

Toru Yoshida

Hideaki Tsuge

Affiliations

Soon will be listed here.

Abstract

Many bacterial pathogens utilize ADP-ribosyltransferases (ARTs) as virulence factors. The critical aspect of ARTs is their target specificity. Each individual ART modifies a specific residue of its substrates, which could be proteins, DNA, or antibiotics. However, the mechanism underlying this specificity is poorly understood. Here, we review the substrate recognition mechanism and target residue specificity based on the available complex structures of ARTs and their substrates. We show that there are common mechanisms of target residue specificity among protein- and DNA-targeting ARTs.

Citing Articles

Pierisin, Cytotoxic and Apoptosis-Inducing DNA ADP-Ribosylating Protein in Cabbage Butterfly.

Takahashi-Nakaguchi A, Horiuchi Y, Yamamoto M, Totsuka Y, Wakabayashi K Toxins (Basel). 2024; 16(6).

PMID: 38922164 PMC: 11209040. DOI: 10.3390/toxins16060270.

Molecular basis of threonine ADP-ribosylation of ubiquitin by bacterial ARTs.

Tan J, Xu Y, Wang X, Yan F, Xian W, Liu X Nat Chem Biol. 2023; 20(4):463-472.

PMID: 37945894 DOI: 10.1038/s41589-023-01475-3.

Intercepting biological messages: Antibacterial molecules targeting nucleic acids during interbacterial conflicts.

Hespanhol J, Karman L, Sanchez-Limache D, Bayer-Santos E Genet Mol Biol. 2023; 46(1 Suppl 2):e20220266.

PMID: 36880694 PMC: 9990079. DOI: 10.1590/1678-4685-GMB-2022-0266.

Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin.

Belyy A, Lindemann F, Roderer D, Funk J, Bardiaux B, Protze J Nat Commun. 2022; 13(1):4202.

PMID: 35858890 PMC: 9300711. DOI: 10.1038/s41467-022-31836-w.

A Structural Approach to Anti-Virulence: A Discovery Pipeline.

McCarthy M, Goncalves M, Powell H, Morey B, Turner M, Merrill A Microorganisms. 2021; 9(12).

PMID: 34946116 PMC: 8704661. DOI: 10.3390/microorganisms9122514.

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