Herwig Grabmayr
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Explore the profile of Herwig Grabmayr including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
128
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Recent Articles
1.
Hopl V, Tiffner A, Wutscher A, Sallinger M, Grabmayr H, Prantl M, et al.
Commun Biol
. 2024 Nov;
7(1):1522.
PMID: 39550503
The activation of the Ca-channel Orai1 via the physiological activator stromal interaction molecule 1 (STIM1) requires structural rearrangements within the entire channel complex involving a series of gating checkpoints. Focusing...
2.
Sallinger M, Humer C, Ong H, Narayanasamy S, Lin Q, Fahrner M, et al.
Proc Natl Acad Sci U S A
. 2024 May;
121(21):e2318874121.
PMID: 38753510
The single-pass transmembrane protein Stromal Interaction Molecule 1 (STIM1), located in the endoplasmic reticulum (ER) membrane, possesses two main functions: It senses the ER-Ca concentration and directly binds to the...
3.
Maltan L, Weiss S, Najjar H, Leopold M, Lindinger S, Hoglinger C, et al.
Nat Commun
. 2023 Mar;
14(1):1286.
PMID: 36890174
Ca release-activated Ca (CRAC) channels, indispensable for the immune system and various other human body functions, consist of two transmembrane (TM) proteins, the Ca-sensor STIM1 in the ER membrane and...
4.
Gamage T, Grabmayr H, Horvath F, Fahrner M, Misceo D, Louch W, et al.
Sci Signal
. 2023 Feb;
16(771):eadd0509.
PMID: 36749824
Stormorken syndrome is a multiorgan hereditary disease caused by dysfunction of the endoplasmic reticulum (ER) Ca sensor protein STIM1, which forms the Ca release-activated Ca (CRAC) channel together with the...
5.
Horvath F, Berlansky S, Maltan L, Grabmayr H, Fahrner M, Derler I, et al.
Protein Sci
. 2023 Jan;
32(3):e4571.
PMID: 36691702
Stromal interaction molecule 1 (STIM1) resides in the endoplasmic reticulum (ER) membrane and senses luminal calcium (Ca ) concentration. STIM1 activation involves a large-scale conformational transition that exposes a STIM1...
6.
Sallinger M, Grabmayr H, Humer C, Bonhenry D, Romanin C, Schindl R, et al.
J Physiol
. 2023 Jan;
602(8):1475-1507.
PMID: 36651592
The family of stromal interaction molecules (STIM) includes two widely expressed single-pass endoplasmic reticulum (ER) transmembrane proteins and additional splice variants that act as precise ER-luminal Ca sensors. STIM proteins...
7.
Augustynek B, Gyimesi G, Dernic J, Sallinger M, Albano G, Klesse G, et al.
Cell Calcium
. 2022 Jul;
105:102616.
PMID: 35792401
In humans, there are three paralogs of the Orai Ca channel that form the core of the store-operated calcium entry (SOCE) machinery. While the STIM-mediated gating mechanism of Orai channels...
8.
Humer C, Berlansky S, Grabmayr H, Sallinger M, Bernhard A, Fahrner M, et al.
Cells
. 2022 Jun;
11(11).
PMID: 35681544
All human life starts with a calcium (Ca) wave. This ion regulates a plethora of cellular functions ranging from fertilisation and birth to development and cell death. A sophisticated system...
9.
Berlansky S, Sallinger M, Grabmayr H, Humer C, Bernhard A, Fahrner M, et al.
Cells
. 2022 Jan;
11(2).
PMID: 35053369
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). This respiratory illness was declared a pandemic by the world health...
10.
Tiffner A, Hopl V, Schober R, Sallinger M, Grabmayr H, Hoglinger C, et al.
Cancers (Basel)
. 2021 Dec;
13(24).
PMID: 34944977
The interplay of SK3, a Ca sensitive K ion channel, with Orai1, a Ca ion channel, has been reported to increase cytosolic Ca levels, thereby triggering proliferation of breast and...