Calcium Signals During SARS-CoV-2 Infection: Assessing the Potential of Emerging Therapies

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2022 Jan 21

PMID 35053369

Authors

Sascha Berlansky

Matthias Sallinger

Herwig Grabmayr

Christina Humer

Andreas Bernhard

Marc Fahrner

Irene Frischauf

Affiliations

Soon will be listed here.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). This respiratory illness was declared a pandemic by the world health organization (WHO) in March 2020, just a few weeks after being described for the first time. Since then, global research effort has considerably increased humanity's knowledge about both viruses and disease. It has also spawned several vaccines that have proven to be key tools in attenuating the spread of the pandemic and severity of COVID-19. However, with vaccine-related skepticism being on the rise, as well as breakthrough infections in the vaccinated population and the threat of a complete immune escape variant, alternative strategies in the fight against SARS-CoV-2 are urgently required. Calcium signals have long been known to play an essential role in infection with diverse viruses and thus constitute a promising avenue for further research on therapeutic strategies. In this review, we introduce the pivotal role of calcium signaling in viral infection cascades. Based on this, we discuss prospective calcium-related treatment targets and strategies for the cure of COVID-19 that exploit viral dependence on calcium signals.

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References

Omer S, Benjamin R, Brewer N, Buttenheim A, Callaghan T, Caplan A . Promoting COVID-19 vaccine acceptance: recommendations from the Lancet Commission on Vaccine Refusal, Acceptance, and Demand in the USA. Lancet. 2021; 398(10317):2186-2192. PMC: 8592561. DOI: 10.1016/S0140-6736(21)02507-1. View

Wen L, Voronina S, Javed M, Awais M, Szatmary P, Latawiec D . Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models. Gastroenterology. 2015; 149(2):481-92.e7. PMC: 4556985. DOI: 10.1053/j.gastro.2015.04.015. View

Wulff H, Christophersen P, Colussi P, Chandy K, Yarov-Yarovoy V . Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019; 18(5):339-357. PMC: 6499689. DOI: 10.1038/s41573-019-0013-8. View

Wang S, Liu Y, Guo J, Wang P, Zhang L, Xiao G . Screening of FDA-Approved Drugs for Inhibitors of Japanese Encephalitis Virus Infection. J Virol. 2017; 91(21). PMC: 5640845. DOI: 10.1128/JVI.01055-17. View

Waldherr L, Tiffner A, Mishra D, Sallinger M, Schober R, Frischauf I . Blockage of Store-Operated Ca Influx by Synta66 is Mediated by Direct Inhibition of the Ca Selective Orai1 Pore. Cancers (Basel). 2020; 12(10). PMC: 7600887. DOI: 10.3390/cancers12102876. View

Wang B, Kovalchuk A, Li D, Rodriguez-Juarez R, Ilnytskyy Y, Kovalchuk I . In search of preventive strategies: novel high-CBD extracts modulate ACE2 expression in COVID-19 gateway tissues. Aging (Albany NY). 2020; 12(22):22425-22444. PMC: 7746344. DOI: 10.18632/aging.202225. View

Straus M, Bidon M, Tang T, Jaimes J, Whittaker G, Daniel S . Inhibitors of L-Type Calcium Channels Show Therapeutic Potential for Treating SARS-CoV-2 Infections by Preventing Virus Entry and Spread. ACS Infect Dis. 2021; 7(10):2807-2815. DOI: 10.1021/acsinfecdis.1c00023. View

Berthelot J, Liote F, Maugars Y, Sibilia J . Lymphocyte Changes in Severe COVID-19: Delayed Over-Activation of STING?. Front Immunol. 2020; 11:607069. PMC: 7736628. DOI: 10.3389/fimmu.2020.607069. View

Solaimanzadeh I . Nifedipine and Amlodipine Are Associated With Improved Mortality and Decreased Risk for Intubation and Mechanical Ventilation in Elderly Patients Hospitalized for COVID-19. Cureus. 2020; 12(5):e8069. PMC: 7219014. DOI: 10.7759/cureus.8069. View

10.

Cao J, Forrest J, Zhang X . A screen of the NIH Clinical Collection small molecule library identifies potential anti-coronavirus drugs. Antiviral Res. 2014; 114:1-10. PMC: 7113785. DOI: 10.1016/j.antiviral.2014.11.010. View

11.

Zhou P, Yang X, Wang X, Hu B, Zhang L, Zhang W . A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579(7798):270-273. PMC: 7095418. DOI: 10.1038/s41586-020-2012-7. View

12.

Omar S, Clarke R, Abdullah H, Brady C, Corry J, Winter H . Respiratory virus infection up-regulates TRPV1, TRPA1 and ASICS3 receptors on airway cells. PLoS One. 2017; 12(2):e0171681. PMC: 5302416. DOI: 10.1371/journal.pone.0171681. View

13.

Di Filippo L, Formenti A, Giustina A . Hypocalcemia: the quest for the cause of a major biochemical feature of COVID-19. Endocrine. 2020; 70(3):463-464. PMC: 7580813. DOI: 10.1007/s12020-020-02525-9. View

14.

Forni G, Mantovani A . COVID-19 vaccines: where we stand and challenges ahead. Cell Death Differ. 2021; 28(2):626-639. PMC: 7818063. DOI: 10.1038/s41418-020-00720-9. View

15.

Dror A, Eisenbach N, Taiber S, Morozov N, Mizrachi M, Zigron A . Vaccine hesitancy: the next challenge in the fight against COVID-19. Eur J Epidemiol. 2020; 35(8):775-779. PMC: 8851308. DOI: 10.1007/s10654-020-00671-y. View

16.

Guihur A, Rebeaud M, Fauvet B, Tiwari S, Weiss Y, Goloubinoff P . Moderate Fever Cycles as a Potential Mechanism to Protect the Respiratory System in COVID-19 Patients. Front Med (Lausanne). 2020; 7:564170. PMC: 7517715. DOI: 10.3389/fmed.2020.564170. View

17.

Zhao Y, Fang C, Zhang Q, Zhang R, Zhao X, Duan Y . Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332. Protein Cell. 2021; 13(9):689-693. PMC: 8533666. DOI: 10.1007/s13238-021-00883-2. View

18.

Rinkenberger N, Schoggins J . Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses. mBio. 2018; 9(1). PMC: 5790917. DOI: 10.1128/mBio.02314-17. View

19.

Fuchs S, Rensing-Ehl A, Speckmann C, Bengsch B, Schmitt-Graeff A, Bondzio I . Antiviral and regulatory T cell immunity in a patient with stromal interaction molecule 1 deficiency. J Immunol. 2011; 188(3):1523-33. PMC: 3262903. DOI: 10.4049/jimmunol.1102507. View

20.

Stauderman K . CRAC channels as targets for drug discovery and development. Cell Calcium. 2018; 74:147-159. DOI: 10.1016/j.ceca.2018.07.005. View