Herbert Y Meltzer
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Explore the profile of Herbert Y Meltzer including associated specialties, affiliations and a list of published articles.
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299
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8035
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Recent Articles
21.
Baltzersen O, Meltzer H, Frokjaer V, Raghava J, Baandrup L, Fagerlund B, et al.
Front Pharmacol
. 2020 May;
11:591.
PMID: 32425802
Background: All current approved antipsychotic drugs against schizophrenia spectrum disorders share affinity for the dopamine receptor (D2R). However, up to one-third of these patients respond insufficiently, and in some cases,...
22.
Maes M, Lu J, Tiwari A, Freeman N, De Luca V, Muller D, et al.
Drug Dev Res
. 2020 May;
82(5):678-684.
PMID: 32394511
Tardive dyskinesia (TD) is a potentially irreversible movement disorder observed following long-term antipsychotic exposure. Its cause is unknown; however, a genetic component has been supported by studies of affected families....
23.
Yoshida K, Maciukiewicz M, Zai C, Goncalves V, Brandl E, Lieberman J, et al.
Prog Neuropsychopharmacol Biol Psychiatry
. 2020 Apr;
102:109952.
PMID: 32335267
Background: Antipsychotics, especially most of the second-generation antipsychotics, have a high risk for metabolic syndrome and antipsychotic-induced weight gain (AIWG). A promoter variant of the leptin (LEP) gene, -2548G/A (rs7799039),...
24.
Meltzer H, Share D, Jayathilake K, Salomon R, Lee M
J Clin Psychopharmacol
. 2020 Apr;
40(3):240-249.
PMID: 32332459
Purpose/background: In addition to clozapine, other atypical antipsychotic drugs pharmacologically similar to clozapine, for example, olanzapine, risperidone, and melperone, are also effective in a similar proportion of treatment-resistant schizophrenia (TRS)...
25.
Huang M, He W, Rajagopal L, Kudwa A, Grigoriadis D, Meltzer H
Pharmacol Biochem Behav
. 2020 Feb;
190:172872.
PMID: 32084491
Valbenazine, a vesicular monoamine transporter 2 (VMAT2, SLC18A2) inhibitor, is a newly approved treatment for tardive dyskinesia. VMAT2 is present in the membrane of secretory vesicles and transports dopamine (DA),...
26.
Karpouzian-Rogers T, Stocks J, Meltzer H, Reilly J
Schizophr Res
. 2019 Nov;
215:314-321.
PMID: 31706786
Objective: Eye movement (EM) measures can serve as biomarkers to evaluate pharmacological effects on brain systems involved in cognition. In recent onset schizophrenia, antipsychotic treatment can improve attentional control on...
27.
Yoshikawa A, Li J, Meltzer H
Pharmacogenomics J
. 2019 Oct;
20(2):260-270.
PMID: 31636356
Stimulation of the serotonin (5-HT)1A receptor (HTR1A) has been shown to contribute to the mechanism of action of some atypical antipsychotic drugs (APDs), including clozapine and lurasidone. A meta-analysis of...
28.
Huang M, He W, Kiss B, Farkas B, Adham N, Meltzer H
J Pharmacol Exp Ther
. 2019 Sep;
371(2):517-525.
PMID: 31511365
Cariprazine is an approved antipsychotic and antidepressant which is a dopamine (DA) D-preferring D/D receptor partial agonist, serotonin (5-HT) 5-HT receptor partial agonist, and 5-HT and 5-HT receptor antagonist, a...
29.
Maciukiewicz M, Tiwari A, Zai C, Gorbovskaya I, Laughlin C, Nurmi E, et al.
Schizophr Res
. 2019 Aug;
212:204-212.
PMID: 31447353
Background: Antipsychotic (AP) medications are the first line of treatment for schizophrenia. However, most conferr a risk of antipsychotic-induced weight gain (AIWG). The objective of this investigation was to conduct...
30.
Alkelai A, Greenbaum L, Heinzen E, Baugh E, Teitelbaum A, Zhu X, et al.
Prog Neuropsychopharmacol Biol Psychiatry
. 2019 Jun;
94:109659.
PMID: 31153890
Tardive dyskinesia (TD) is an adverse movement disorder induced by chronic treatment with antipsychotics drugs. The contribution of common genetic variants to TD susceptibility has been investigated in recent years,...