Henrik Ortsater
Overview
Explore the profile of Henrik Ortsater including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
972
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Recent Articles
1.
Schnabellehner S, Kraft M, Schoofs H, Ortsater H, Makinen T
Vasc Biol
. 2023 Dec;
6(1).
PMID: 38051669
Endothelial cells (ECs) of blood and lymphatic vessels have distinct identity markers that define their specialized functions. Recently, hybrid vasculatures with both blood and lymphatic vessel-specific features have been discovered...
2.
Petkova M, Kraft M, Stritt S, Martinez-Corral I, Ortsater H, Vanlandewijck M, et al.
J Exp Med
. 2023 Jan;
220(4).
PMID: 36688917
Oncogenic mutations in PIK3CA, encoding p110α-PI3K, are a common cause of venous and lymphatic malformations. Vessel type-specific disease pathogenesis is poorly understood, hampering development of efficient therapies. Here, we reveal...
3.
Zhang Y, Ortsater H, Martinez-Corral I, Makinen T
Life Sci Alliance
. 2022 Aug;
5(11).
PMID: 35961777
The developmental origins of lymphatic endothelial cells (LECs) have been under intense research after a century-long debate. Although previously thought to be of solely venous endothelial origin, additional sources of...
4.
Figueiredo B, Ferreira F, Barbosa A, Dos Santos C, Ortsater H, Rafacho A
Life Sci
. 2021 Oct;
286:120026.
PMID: 34627773
Aims: Glucocorticoids (GC) in excess cause glucose intolerance and dyslipidemia due to their diabetogenic actions. Conceptually, antidiabetic drugs should attenuate these side effects. Thus, we evaluated whether the coadministration of...
5.
Ortsater H, Hernandez-Vasquez M, Ulvmar M, Gow A, Makinen T
Genesis
. 2021 Aug;
59(7-8):e23439.
PMID: 34338433
Luminal valves of collecting lymphatic vessels are critical for maintaining unidirectional flow of lymph and their dysfunction underlies several forms of primary lymphedema. Here, we report on the generation of...
6.
Frye M, Stritt S, Ortsater H, Hernandez Vasquez M, Kaakinen M, Vicente A, et al.
Elife
. 2020 Sep;
9.
PMID: 32897857
Endothelial integrity is vital for homeostasis and adjusted to tissue demands. Although fluid uptake by lymphatic capillaries is a critical attribute of the lymphatic vasculature, the barrier function of collecting...
7.
Lytrivi M, Ghaddar K, Lopes M, Rosengren V, Piron A, Yi X, et al.
BMC Genomics
. 2020 Aug;
21(1):590.
PMID: 32847508
Background: Prolonged exposure to elevated free fatty acids induces β-cell failure (lipotoxicity) and contributes to the pathogenesis of type 2 diabetes. In vitro exposure of β-cells to the saturated free...
8.
Martinez-Corral I, Zhang Y, Petkova M, Ortsater H, Sjoberg S, Castillo S, et al.
Nat Commun
. 2020 Jun;
11(1):2869.
PMID: 32513927
Lymphatic malformations (LMs) are debilitating vascular anomalies presenting with large cysts (macrocystic) or lesions that infiltrate tissues (microcystic). Cellular mechanisms underlying LM pathology are poorly understood. Here we show that...
9.
Frye M, Taddei A, Dierkes C, Martinez-Corral I, Fielden M, Ortsater H, et al.
Nat Commun
. 2018 Apr;
9(1):1511.
PMID: 29666442
Tissue and vessel wall stiffening alters endothelial cell properties and contributes to vascular dysfunction. However, whether extracellular matrix (ECM) stiffness impacts vascular development is not known. Here we show that...
10.
Wang Y, Jin Y, Mae M, Zhang Y, Ortsater H, Betsholtz C, et al.
Development
. 2017 Aug;
144(19):3590-3601.
PMID: 28851707
Tissue fluid drains through blind-ended lymphatic capillaries, via smooth muscle cell (SMC)-covered collecting vessels into venous circulation. Both defective SMC recruitment to collecting vessels and ectopic recruitment to lymphatic capillaries...