Henrietta Dehmlow
Overview
Explore the profile of Henrietta Dehmlow including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
187
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0
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Recent Articles
1.
Dehmlow H, Alvarez Sanchez R, Bachmann S, Bissantz C, Bliss F, Conde-Knape K, et al.
Bioorg Med Chem Lett
. 2013 Jul;
23(16):4627-32.
PMID: 23831134
A series of non-steroidal GPBAR1 (TGR5) agonists was developed from a hit in a high-throughput screening campaign. Lead identification efforts produced biphenyl-4-carboxylic acid derivative (R)-22, which displayed a robust secretion...
2.
Martin R, Bissantz C, Gavelle O, Kuratli C, Dehmlow H, Richter H, et al.
ChemMedChem
. 2012 Dec;
8(4):569-76.
PMID: 23225346
Potency with potential: 2-Phenoxy-nicotinamides were identified as potent agonists at the GPBAR1 receptor, a target in the treatment of obesity, type 2 diabetes and metabolic syndrome. Extensive structure-activity relationship studies...
3.
Staedler D, Chapuis-Bernasconi C, Dehmlow H, Fischer H, Juillerat-Jeanneret L, Aebi J
J Med Chem
. 2012 Apr;
55(11):4990-5002.
PMID: 22533316
Ten oxidosqualene cyclase inhibitors with high efficacy as cholesterol-lowering agents and of different chemical structure classes were evaluated as potential anticancer agents against human cancer cells from various tissue origins...
4.
Kratochwil N, Gatti-McArthur S, Hoener M, Lindemann L, Christ A, Green L, et al.
Curr Top Med Chem
. 2011 Apr;
11(15):1902-24.
PMID: 21470172
G protein-coupled receptors (GPCRs) share a common architecture consisting of seven transmembrane (TM) domains. Various lines of evidence suggest that this fold provides a generic binding pocket within the TM...
5.
Peters J, Kuhne H, Dehmlow H, Grether U, Conte A, Hainzl D, et al.
Bioorg Med Chem Lett
. 2010 Aug;
20(18):5426-30.
PMID: 20724150
Pyrido pyrimidinones are selective agonists of the human high affinity niacin receptor GPR109A (HM74A). They show no activity on the highly homologous low affinity receptor GPR109B (HM74). Starting from a...
6.
Ratni H, Blum-Kaelin D, Dehmlow H, Hartman P, Jablonski P, Masciadri R, et al.
Bioorg Med Chem Lett
. 2009 Feb;
19(6):1654-7.
PMID: 19231176
A series of tetrahydro-cyclopenta[b]indoles modulating the activity of the liver-X-receptor (LXR) were derived from a high throughput screening hit. The potency and selectivity for LXRbeta versus LXRalpha was improved. One...
7.
Balliano G, Dehmlow H, Oliaro-Bosso S, Scaldaferri M, Taramino S, Viola F, et al.
Bioorg Med Chem Lett
. 2009 Jan;
19(3):718-23.
PMID: 19119009
A series of 25 compounds, some of which previously were described as inhibitors of human liver microsomal oxidosqualene cyclase (OSC), were tested as inhibitors of Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis...
8.
Panday N, Benz J, Blum-Kaelin D, Bourgeaux V, Dehmlow H, Hartman P, et al.
Bioorg Med Chem Lett
. 2006 Aug;
16(19):5231-7.
PMID: 16876993
A series of branched and unbranched anilinohexafluoroisopropanols related to the known sulfonamide T0901317 were prepared and evaluated as activators/modulators of both LXRalpha and LXRbeta. A structure-activity relationship was established and...
9.
Telford D, Lipson S, Barrett P, Sutherland B, Edwards J, Aebi J, et al.
Arterioscler Thromb Vasc Biol
. 2005 Oct;
25(12):2608-14.
PMID: 16210564
Objective: Inhibition of 2,3-oxidosqualene:lanosterol cyclase (OSC), an enzyme in the cholesterol synthesis pathway, has the unique ability to inhibit cholesterol synthesis while simultaneously enhancing oxysterol synthesis. Our objectives were to...
10.
Berger Y, Dehmlow H, Blum-Kaelin D, Kitas E, Loffler B, Aebi J, et al.
J Med Chem
. 2005 Jan;
48(2):483-98.
PMID: 15658862
Endothelin-1 (ET-1) is mitogenic and/or antiapoptotic in human cancers, and antagonists to ET-1 receptors are under evaluation for cancer treatment. Inhibition of ET-1 activation by the endothelin-converting enzymes 1(a)(-)(d) (ECE-1(a)(-)(d);...