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Henric Olsson

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Articles 19
Citations 515
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Recent Articles
1.
Bradley J, OShea P, Wrench C, Mattsson J, Paulin R, Overed-Sayer C, et al.
SLAS Discov . 2025 Mar; 32:100223. PMID: 40024445
Senescent cells contribute to the pathogenesis of idiopathic pulmonary fibrosis (IPF), a disease with significant unmet need and therefore, there is an interest in discovering new drug targets that regulate...
2.
Malmhall C, Calven J, Weidner J, Johansson K, Ramos-Ramirez P, Boberg E, et al.
Clin Transl Allergy . 2025 Mar; 15(3):e70042. PMID: 40022441
Background: Sex differences have been reported in the incidence, prevalence and severity of asthma. Previous findings from animal models have revealed sex-related differences in inflammatory pathways that may contribute to...
3.
Burren O, Dhindsa R, Deevi S, Wen S, Nag A, Mitchell J, et al.
Nat Genet . 2024 Aug; 56(9):1832-1840. PMID: 39192095
Telomeres protect chromosome ends from damage and their length is linked with human disease and aging. We developed a joint telomere length metric, combining quantitative PCR and whole-genome sequencing measurements...
4.
Merino-Vico A, van Hamburg J, Tuijnenburg P, Frazzei G, Al-Soudi A, Bonasia C, et al.
J Autoimmun . 2023 Nov; 142:103133. PMID: 37931331
B lineage cells are critically involved in ANCA-associated vasculitis (AAV), evidenced by alterations in circulating B cell subsets and beneficial clinical effects of rituximab (anti-CD20) therapy. This treatment renders a...
5.
Weidner J, Kolosionek E, Holmila R, Ax E, Garreau M, Gnerlich F, et al.
Mol Ther Nucleic Acids . 2023 Sep; 33:898-907. PMID: 37680982
MicroRNAs are attractive therapeutic targets in many diseases, including chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Among microRNA inhibitors antimiRs have been proven successful in lowering aberrant microRNA levels...
6.
Ramos-Ramirez P, Liu J, Mogren S, Gregory J, Noreby M, Petren A, et al.
J Immunol Res . 2023 Feb; 2023:9393497. PMID: 36761882
Background: Asthma is a chronic inflammatory disease with structural changes in the lungs defined as airway remodelling. Mast cell responses are important in asthma as they, upon activation, release mediators...
7.
Cui Y, Gutierrez S, Ariai S, Oberg L, Thorn K, Gehrmann U, et al.
Front Immunol . 2022 Nov; 13:998059. PMID: 36341326
Iron is a key element for systemic oxygen delivery and cellular energy metabolism. Thus regulation of systemic and local iron metabolism is key for maintaining energy homeostasis. Significant changes in...
8.
Reinke S, Naz S, Chaleckis R, Gallart-Ayala H, Kolmert J, Kermani N, et al.
Eur Respir J . 2021 Nov; 59(6). PMID: 34824054
Introduction: Asthma is a heterogeneous disease with poorly defined phenotypes. Patients with severe asthma often receive multiple treatments including oral corticosteroids (OCS). Treatment may modify the observed metabotype, rendering it...
9.
Wang Q, Dhindsa R, Carss K, Harper A, Nag A, Tachmazidou I, et al.
Nature . 2021 Aug; 597(7877):527-532. PMID: 34375979
Genome-wide association studies have uncovered thousands of common variants associated with human disease, but the contribution of rare variants to common disease remains relatively unexplored. The UK Biobank contains detailed...
10.
Dhindsa R, Mattsson J, Nag A, Wang Q, Wain L, Allen R, et al.
Commun Biol . 2021 Mar; 4(1):392. PMID: 33758299
Idiopathic pulmonary fibrosis (IPF) is a fatal disorder characterised by progressive, destructive lung scarring. Despite substantial progress, the genetic determinants of this disease remain incompletely defined. Using whole genome and...