Quanli Wang
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Explore the profile of Quanli Wang including associated specialties, affiliations and a list of published articles.
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57
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3841
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Recent Articles
1.
Spargo T, Sands C, Juan I, Mitchell J, Ravanmehr V, Butts J, et al.
Cell Rep
. 2025 Mar;
:115355.
PMID: 40056900
Despite its significant heritability, the genetic basis of Parkinson's disease (PD) remains incompletely understood. Here, in analyzing whole-genome sequence data from 3,809 PD cases and 247,101 controls in the UK...
2.
Mitchell J, Camacho N, Shea P, Stopsack K, Joseph V, Burren O, et al.
Nat Commun
. 2025 Feb;
16(1):1779.
PMID: 39971927
To assess the contribution of rare coding germline genetic variants to prostate cancer risk and severity, we perform here a meta-analysis of 37,184 prostate cancer cases and 331,329 male controls...
3.
Wen S, Kuri-Morales P, Hu F, Nag A, Tachmazidou I, Deevi S, et al.
Nat Genet
. 2025 Feb;
57(3):572-582.
PMID: 39948438
The impact of genetic ancestry on the development of clonal hematopoiesis (CH) remains largely unexplored. Here, we compared CH in 136,401 participants from the Mexico City Prospective Study (MCPS) to...
4.
Garg M, Karpinski M, Matelska D, Middleton L, Burren O, Hu F, et al.
Nat Genet
. 2024 Sep;
56(9):1821-1831.
PMID: 39261665
The emergence of biobank-level datasets offers new opportunities to discover novel biomarkers and develop predictive algorithms for human disease. Here, we present an ensemble machine-learning framework (machine learning with phenotype...
5.
Burren O, Dhindsa R, Deevi S, Wen S, Nag A, Mitchell J, et al.
Nat Genet
. 2024 Aug;
56(9):1832-1840.
PMID: 39192095
Telomeres protect chromosome ends from damage and their length is linked with human disease and aging. We developed a joint telomere length metric, combining quantitative PCR and whole-genome sequencing measurements...
6.
Mitchell J, Camacho N, Shea P, Stopsack K, Joseph V, Burren O, et al.
medRxiv
. 2024 May;
PMID: 38766261
The etiology of prostate cancer, the second most common cancer in men globally, has a strong heritable component. While rare coding germline variants in several genes have been identified as...
7.
Middleton L, Melas I, Vasavda C, Raies A, Rozemberczki B, Dhindsa R, et al.
Sci Adv
. 2024 May;
10(19):eadj1424.
PMID: 38718126
The ongoing expansion of human genomic datasets propels therapeutic target identification; however, extracting gene-disease associations from gene annotations remains challenging. Here, we introduce Mantis-ML 2.0, a framework integrating AstraZeneca's Biological...
8.
Huynh L, Su J, Wang Q, Stringer L, Switzer A, Gasparatos A
Nat Commun
. 2024 Apr;
15(1):2870.
PMID: 38594246
Traditional approaches to coastal defence often struggle to reduce the risks of accelerated climate change. Incorporating nature-based components into coastal defences may enhance adaptation to climate change with added benefits,...
9.
Zhao Y, Chukanova M, Kentistou K, Fairhurst-Hunter Z, Siegert A, Jia R, et al.
Nat Genet
. 2024 Apr;
56(4):579-584.
PMID: 38575728
Obesity is a major risk factor for many common diseases and has a substantial heritable component. To identify new genetic determinants, we performed exome-sequence analyses for adult body mass index...
10.
Dhindsa R, Burren O, Sun B, Prins B, Matelska D, Wheeler E, et al.
Nature
. 2023 Oct;
622(7982):339-347.
PMID: 37794183
Integrating human genomics and proteomics can help elucidate disease mechanisms, identify clinical biomarkers and discover drug targets. Because previous proteogenomic studies have focused on common variation via genome-wide association studies,...