Hemant Giri
Overview
Explore the profile of Hemant Giri including associated specialties, affiliations and a list of published articles.
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25
Citations
412
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Recent Articles
1.
Giri H, Biswas I, Rezaie A
J Thromb Haemost
. 2024 Jan;
22(4):905-914.
PMID: 38266676
Thrombomodulin (TM) is a type 1 receptor best known for its function as an anticoagulant cofactor for thrombin activation of protein C on the surface of vascular endothelial cells. In...
2.
Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin
Biswas I, Giri H, Panicker S, Rezaie A
Arterioscler Thromb Vasc Biol
. 2024 Jan;
44(3):603-616.
PMID: 38174561
Background: Cleavage of the extracellular domain of PAR1 (protease-activated receptor 1) by thrombin at Arg41 and by APC (activated protein C) at Arg46 initiates paradoxical cytopathic and cytoprotective signaling in...
3.
Giri H, Biswas I, Rezaie A
Arterioscler Thromb Vasc Biol
. 2023 Dec;
44(2):352-365.
PMID: 38059351
Background: We recently demonstrated that deletion of thrombomodulin gene from endothelial cells results in upregulation of proinflammatory phenotype. In this study, we investigated the molecular basis for the altered phenotype...
4.
Chandel S, Kumaragurubaran R, Giri H, Dixit M
Methods Mol Biol
. 2023 Sep;
2711:147-162.
PMID: 37776455
This protocol describes a simple and an economical method for isolation of endothelial cells from human umbilical vein. Umbilical cord is easily available postpartum following informed consent, and the method...
5.
Giri H, Dixit M
Methods Mol Biol
. 2023 Sep;
2711:47-62.
PMID: 37776448
Endothelial cells lining the inner surface of blood vessels and lymphatic vessels play an indispensable role in vascular homeostasis. Apart from regulating vessel tone and forming an anti-thrombotic and anti-atherosclerotic...
6.
Giri H, Biswas I, Rezaie A
J Thromb Haemost
. 2023 Jan;
21(1):133-144.
PMID: 36695376
Background: In addition to its anticoagulant function in downregulating thrombin generation, activated protein C (APC) evokes pleiotropic cytoprotective signaling activities when it binds to endothelial protein C receptor (EPCR) to...
7.
Giri H, Srivastava A, Naik U
Vascul Pharmacol
. 2022 Jul;
145:107088.
PMID: 35798237
Thrombin-induced endothelial permeability is associated with various pathological conditions. Apoptosis signal-regulating kinase-1 (ASK1), one of the upstream MAP3K, has been reported to be an important regulator of endothelial stress and...
8.
Biswas I, Panicker S, Giri H, Cai X, Rezaie A
Blood Adv
. 2021 Nov;
6(3):931-945.
PMID: 34768285
Plasmodium falciparum-derived histidine-rich protein II (HRPII) has been shown to inhibit heparin-dependent anticoagulant activity of antithrombin (AT) and induce inflammation in vitro and in vivo. In a recent study, we...
9.
Biswas I, Panicker S, Cai X, Giri H, Rezaie A
Cell Physiol Biochem
. 2021 Oct;
55(5):605-617.
PMID: 34655467
Background/aims: Binding of histones to molecular pattern recognition receptors on endothelial cells and leukocytes provokes proinflammatory responses and promotes activation of coagulation. Histones also bind therapeutic heparins, thereby neutralizing their...
10.
Giri H, Panicker S, Cai X, Biswas I, Weiler H, Rezaie A
Proc Natl Acad Sci U S A
. 2021 Apr;
118(11).
PMID: 33836597
Thrombomodulin (TM) is a thrombin receptor on endothelial cells that is involved in promoting activation of the anticoagulant protein C pathway during blood coagulation. TM also exerts protective anti-inflammatory properties...