Helen E Stevens
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Explore the profile of Helen E Stevens including associated specialties, affiliations and a list of published articles.
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17
Citations
3282
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Recent Articles
1.
Cutler A, Oliveira J, Ferreira R, Challis B, Walker N, Caddy S, et al.
Wellcome Open Res
. 2017 Aug;
2:28.
PMID: 28815218
Background: The infection of a participant with norovirus during the adaptive study of interleukin-2 dose on regulatory T cells in type 1 diabetes (DILT1D) allowed a detailed insight into the...
2.
Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2
Pekalski M, Rubio Garcia A, Ferreira R, Rainbow D, Smyth D, Mashar M, et al.
JCI Insight
. 2017 Aug;
2(16).
PMID: 28814669
The maintenance of peripheral naive T lymphocytes in humans is dependent on their homeostatic division, not continuing emigration from the thymus, which undergoes involution with age. However, postthymic maintenance of...
3.
Todd J, Evangelou M, Cutler A, Pekalski M, Walker N, Stevens H, et al.
PLoS Med
. 2016 Oct;
13(10):e1002139.
PMID: 27727279
Background: Interleukin-2 (IL-2) has an essential role in the expansion and function of CD4+ regulatory T cells (Tregs). Tregs reduce tissue damage by limiting the immune response following infection and...
4.
Downes K, Marcovecchio M, Clarke P, Cooper J, Ferreira R, Howson J, et al.
Diabetologia
. 2013 Nov;
57(2):366-72.
PMID: 24264051
Aims/hypothesis: Type 1 diabetes is a common autoimmune disease that has genetic and environmental determinants. Variations within the IL2 and IL2RA (also known as CD25) gene regions are associated with...
5.
Pekalski M, Ferreira R, Coulson R, Cutler A, Guo H, Smyth D, et al.
J Immunol
. 2013 Feb;
190(6):2554-66.
PMID: 23418630
As the thymus involutes with age, the maintenance of peripheral naive T cells in humans becomes strongly dependent on peripheral cell division. However, mechanisms that orchestrate homeostatic division remain unclear....
6.
Lo B, Swafford A, Shafer-Weaver K, Jerome L, Rakhlin L, Mathern D, et al.
J Transl Med
. 2011 Nov;
9:203.
PMID: 22123298
Background: The detection of insulin autoantibodies (IAA) aids in the prediction of autoimmune diabetes development. However, the long-standing, gold standard 125I-insulin radiobinding assay (RBA) has low reproducibility between laboratories, long...
7.
Saleh N, Raj S, Smyth D, Wallace C, Howson J, Bell L, et al.
Diabetes Metab Res Rev
. 2011 Nov;
27(8):838-43.
PMID: 22069270
Background: The genetic basis of the autoimmune disease type 1 diabetes (T1D) has now been largely determined, so now we can compare these findings with emerging genetic knowledge of disorders...
8.
Davison L, Cooper J, Cope N, Wilson N, Smyth D, Howson J, et al.
Hum Mol Genet
. 2011 Oct;
21(2):322-33.
PMID: 21989056
The chromosome 16p13 region has been associated with several autoimmune diseases, including type 1 diabetes (T1D) and multiple sclerosis (MS). CLEC16A has been reported as the most likely candidate gene...
9.
Yang J, Downes K, Howson J, Nutland S, Stevens H, Walker N, et al.
BMC Med Genet
. 2011 Apr;
12:59.
PMID: 21524304
Background: Linkage and congenic strain analyses using the nonobese diabetic (NOD) mouse as a model for human type 1 autoimmune diabetes (T1D) have identified several NOD mouse Idd (insulin dependent...
10.
Wang T, Zhang F, Richards J, Kestenbaum B, van Meurs J, Berry D, et al.
Lancet
. 2010 Jun;
376(9736):180-8.
PMID: 20541252
Background: Vitamin D is crucial for maintenance of musculoskeletal health, and might also have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D concentrations include sun exposure and diet,...