Helen E Jolin
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Explore the profile of Helen E Jolin including associated specialties, affiliations and a list of published articles.
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28
Citations
2935
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Recent Articles
1.
Clark P, Gogoi M, Rodriguez-Rodriguez N, Ferreira A, Murphy J, Walker J, et al.
Nat Commun
. 2024 Sep;
15(1):7809.
PMID: 39242588
Innate lymphoid cells (ILCs) are critical in maintaining tissue homeostasis, and during infection and inflammation. Here we identify, by using combinatorial reporter mice, a rare ILC progenitor (ILCP) population, resident...
2.
Gogoi M, Clark P, Ferreira A, Rodriguez Rodriguez N, Heycock M, Ko M, et al.
Nature
. 2024 Aug;
632(8026):885-892.
PMID: 39112698
Migration and homing of immune cells are critical for immune surveillance. Trafficking is mediated by combinations of adhesion and chemokine receptors that guide immune cells, in response to chemokine signals,...
3.
Szeto A, Clark P, Ferreira A, Heycock M, Griffiths E, Jou E, et al.
Science
. 2024 Jun;
384(6703):eadl0370.
PMID: 38935708
Innate lymphoid cells (ILCs) and adaptive T lymphocytes promote tissue homeostasis and protective immune responses. Their production depends on the transcription factor GATA3, which is further elevated specifically in ILC2s...
4.
Ferreira A, Szeto A, Clark P, Crisp A, Kozik P, Jolin H, et al.
Immunity
. 2023 Jun;
56(7):1468-1484.e7.
PMID: 37285842
Type 2 immune responses are critical in tissue homeostasis, anti-helminth immunity, and allergy. T helper 2 (Th2) cells produce interleukin-4 (IL-4), IL-5, and IL-13 from the type 2 gene cluster...
5.
Szeto A, Ferreira A, Mannion J, Clark P, Sivasubramaniam M, Heycock M, et al.
Nat Immunol
. 2022 Dec;
24(1):123-135.
PMID: 36550322
Naive CD4 T lymphocytes initially undergo antigen-specific activation to promote a broad-spectrum response before adopting bespoke cytokine expression profiles shaped by intercellular microenvironmental cues, resulting in pathogen-focused modular cytokine responses....
6.
Rodriguez-Rodriguez N, Clark P, Gogoi M, Ferreira A, Kerscher B, Crisp A, et al.
Proc Natl Acad Sci U S A
. 2022 Nov;
119(49):e2203454119.
PMID: 36442116
The development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a previously unexpected complexity in ILC hematopoiesis. Using novel polychromic mice to achieve higher phenotypic resolution, we...
7.
Jou E, Rodriguez-Rodriguez N, Ferreira A, Jolin H, Clark P, Sawmynaden K, et al.
Sci Immunol
. 2022 Jun;
7(72):eabn0175.
PMID: 35658010
Interleukin-25 (IL-25) and group 2 innate lymphoid cells (ILC2s) defend the host against intestinal helminth infection and are associated with inappropriate allergic reactions. IL-33-activated ILC2s were previously found to augment...
8.
Cosway E, White A, Parnell S, Schweighoffer E, Jolin H, Bacon A, et al.
Sci Immunol
. 2022 Mar;
7(69):eabn3286.
PMID: 35275754
Therapeutic interventions used for cancer treatment provoke thymus damage and limit the recovery of protective immunity. Here, we show that eosinophils are an essential part of an intrathymic type 2...
9.
Bidault G, Virtue S, Petkevicius K, Jolin H, Dugourd A, Guenantin A, et al.
Nat Metab
. 2021 Sep;
3(9):1150-1162.
PMID: 34531575
Macrophages exhibit a spectrum of activation states ranging from classical to alternative activation. Alternatively, activated macrophages are involved in diverse pathophysiological processes such as confining tissue parasites, improving insulin sensitivity...
10.
Lok L, Walker J, Jolin H, Scanlon S, Ishii M, Fallon P, et al.
Front Immunol
. 2021 Sep;
12:711907.
PMID: 34484215
Group 2 innate lymphoid cells (ILC2s) are early effectors of mucosal type 2 immunity, producing cytokines such as interleukin (IL)-13 to mediate responses to helminth infection and allergen-induced inflammation. ILC2s...