Helen E Jolin
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Explore the profile of Helen E Jolin including associated specialties, affiliations and a list of published articles.
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28
Citations
2935
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Recent Articles
11.
Ferreira A, Szeto A, Heycock M, Clark P, Walker J, Crisp A, et al.
Nat Immunol
. 2021 Jan;
22(2):166-178.
PMID: 33432227
Type 2 innate lymphoid cells (ILC2) contribute to immune homeostasis, protective immunity and tissue repair. Here we demonstrate that functional ILC2 cells can arise in the embryonic thymus from shared...
12.
Panova V, Gogoi M, Rodriguez-Rodriguez N, Sivasubramaniam M, Jolin H, Heycock M, et al.
Mucosal Immunol
. 2020 May;
14(1):26-37.
PMID: 32457448
Type-2 immunity is characterised by interleukin (IL)-4, IL-5 and IL-13, eosinophilia, mucus production, IgE, and alternatively activated macrophages (AAM). However, despite the lack of neutrophil chemoattractants such as CXCL1, neutrophils,...
13.
Lu Y, Basatemur G, Scott I, Chiarugi D, Clement M, Harrison J, et al.
Immunity
. 2020 Apr;
52(5):782-793.e5.
PMID: 32272082
Splenic red pulp macrophages (RPMs) contribute to erythrocyte homeostasis and are required for iron recycling. Heme induces the expression of SPIC transcription factor in monocyte-derived macrophages and promotes their differentiation...
14.
Damgaard R, Jolin H, Allison M, Davies S, Titheradge H, McKenzie A, et al.
Cell Death Differ
. 2020 Apr;
27(5):1457-1474.
PMID: 32231246
Methionine-1 (M1)-linked polyubiquitin chains conjugated by the linear ubiquitin chain assembly complex (LUBAC) control NF-κB activation, immune homoeostasis, and prevents tumour necrosis factor (TNF)-induced cell death. The deubiquitinase OTULIN negatively...
15.
Rana B, Jou E, Barlow J, Rodriguez-Rodriguez N, Walker J, Knox C, et al.
J Exp Med
. 2019 Jun;
216(9):1999-2009.
PMID: 31248899
Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less...
16.
Walker J, Clark P, Crisp A, Barlow J, Szeto A, Ferreira A, et al.
Immunity
. 2019 May;
51(1):104-118.e7.
PMID: 31128961
Innate lymphoid cells (ILCs) play strategic roles in tissue homeostasis and immunity. ILCs arise from lymphoid progenitors undergoing lineage restriction and the development of specialized ILC subsets. We generated "5x...
17.
Kerscher B, Barlow J, Rana B, Jolin H, Gogoi M, Bartholomew M, et al.
Front Immunol
. 2019 Apr;
10:678.
PMID: 31024538
Group 2 innate lymphoid cells (ILC2) increase in frequency in eczema and allergic asthma patients, and thus represent a new therapeutic target cell for type-2 immune-mediated disease. The bromodomain and...
18.
Halim T, Rana B, Walker J, Kerscher B, Knolle M, Jolin H, et al.
Immunity
. 2018 Jun;
48(6):1195-1207.e6.
PMID: 29907525
The local regulation of type 2 immunity relies on dialog between the epithelium and the innate and adaptive immune cells. Here we found that alarmin-induced expression of the co-stimulatory molecule...
19.
Lucken-Ardjomande Hasler S, Vallis Y, Jolin H, Mckenzie A, McMahon H
J Cell Sci
. 2014 Sep;
127(Pt 21):4602-19.
PMID: 25189622
Lipid droplets are found in all cell types. Normally present at low levels in the brain, they accumulate in tumours and are associated with neurodegenerative diseases. However, little is known...
20.
Wong S, Walker J, Jolin H, Drynan L, Hams E, Camelo A, et al.
Nat Immunol
. 2012 Jan;
13(3):229-36.
PMID: 22267218
Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common...