Helen E Blackwell
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Explore the profile of Helen E Blackwell including associated specialties, affiliations and a list of published articles.
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131
Citations
2878
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Recent Articles
1.
Chen L, Quinn L, York J, Polaske T, Nelson A, Appadoo V, et al.
ACS Omega
. 2025 Mar;
10(7):7295-7305.
PMID: 40028086
The ability to prevent bacterial adhesion on surfaces and to facilitate the removal of bacteria once they have already contaminated or colonized a surface is important in a broad range...
2.
Dolph L, Santa E, Stoutland I, Mesa K, Dickson C, Blackwell H, et al.
ACS Chem Biol
. 2025 Feb;
20(2):412-420.
PMID: 39945376
We report silyl-lipid derivatives of -acyl l-homoserine lactones (AHLs) that have nanomolar activities in LuxR-type quorum sensing receptors in Gram-negative bacterial pathogens. A collection of silyl-lipid AHLs were designed and...
3.
Slinger B, Banerjee S, Chandler J, Blackwell H
ACS Chem Biol
. 2024 Dec;
19(12):2557-2568.
PMID: 39636707
Quorum sensing (QS) is a prominent chemical communication mechanism used by common bacteria to regulate group behaviors at high cell density, including many processes important in pathogenesis. There is growing...
4.
Woods K, Akhter S, Rodriguez B, Townsend K, Smith N, Smith B, et al.
Microbiol Spectr
. 2024 Jul;
12(9):e0068124.
PMID: 39046261
Importance: Quorum sensing (QS) regulates many aspects of bacterial pathogenesis and has attracted much interest as a target for anti-virulence therapies over the past 30 years, for example, antagonists of...
5.
Eisenbraun E, Vulpis T, Prosser B, Horswill A, Blackwell H
J Am Chem Soc
. 2024 Jun;
146(23):15941-15954.
PMID: 38832917
The pathogen uses a chemical signaling process, i.e., quorum sensing (QS), to form robust biofilms and cause human infection. Many questions remain about QS in , as it uses this...
6.
Manson D, Ananiev G, Guo S, Ericksen S, Santa E, Blackwell H
ACS Infect Dis
. 2024 May;
10(6):2333-2334.
PMID: 38813620
No abstract available.
7.
Polaske T, West K, Zhao K, Widner D, York J, Blackwell H
Isr J Chem
. 2024 May;
63(5-6).
PMID: 38765792
is a ubiquitous bacterium that has become a major threat to human health due to its extensive toxin production and tremendous capacity for antibiotic resistance (e.g., MRSA "superbug" infections). Amid...
8.
Woods K, Akhter S, Rodriguez B, Townsend K, Smith N, Smith B, et al.
bioRxiv
. 2024 Apr;
PMID: 38559250
Quorum sensing (QS) is a cell-cell signaling system that enables bacteria to coordinate population density-dependent changes in behavior. This chemical communication pathway is mediated by diffusible -acyl L-homoserine lactone signals...
9.
Manson D, Ananiev G, Guo S, Ericksen S, Santa E, Blackwell H
ACS Infect Dis
. 2024 Mar;
10(4):1212-1221.
PMID: 38506163
The opportunistic pathogen controls almost 10% of its genome, including myriad virulence genes, via a cell-to-cell chemical communication system called quorum sensing (QS). Small molecules that either inhibit or activate...
10.
West K, Ma S, Pensinger D, Tucholski T, Tiambeng T, Eisenbraun E, et al.
Biochemistry
. 2023 Sep;
62(19):2878-2892.
PMID: 37699554
Bacteria can use chemical signals to assess their local population density in a process called quorum sensing (QS). Many of these bacteria are common pathogens, including Gram-positive bacteria that utilize...