Heledd H Griffiths
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Explore the profile of Heledd H Griffiths including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
270
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Recent Articles
1.
Watt N, Griffiths H, Hooper N
Front Cell Dev Biol
. 2014 Nov;
2:41.
PMID: 25364748
Dysregulation of neuronal zinc homeostasis plays a major role in many processes related to brain aging and neurodegenerative diseases, including Alzheimer's disease (AD). Yet, despite the critical role of zinc...
2.
Rushworth J, Ahmed A, Griffiths H, Pollock N, Hooper N, Millner P
Biosens Bioelectron
. 2014 Feb;
56:83-90.
PMID: 24480125
Alzheimer's disease (AD) is the most common form of dementia, with over 37 million sufferers worldwide and a global cost of over $600 billion. There is currently no cure for...
3.
Watt N, Griffiths H, Hooper N
Prion
. 2013 Jun;
7(3):203-8.
PMID: 23764834
Zinc, the most abundant trace metal in the brain, has numerous functions in health and disease. It is released into the synaptic cleft alongside glutamate and this connection between zinc...
4.
Rushworth J, Griffiths H, Watt N, Hooper N
J Biol Chem
. 2013 Feb;
288(13):8935-51.
PMID: 23386614
Soluble oligomers of the amyloid-β (Aβ) peptide cause neurotoxicity, synaptic dysfunction, and memory impairments that underlie Alzheimer disease (AD). The cellular prion protein (PrP(C)) was recently identified as a high...
5.
Watt N, Taylor D, Kerrigan T, Griffiths H, Rushworth J, Whitehouse I, et al.
Nat Commun
. 2012 Oct;
3:1134.
PMID: 23072804
Zinc is released into the synaptic cleft upon exocytotic stimuli, although the mechanism for its reuptake into neurons is unresolved. Here we show that the cellular prion protein enhances the...
6.
Griffiths H, Whitehouse I, Hooper N
Prion
. 2012 Mar;
6(3):217-22.
PMID: 22449984
Alzheimer disease (AD) is characterized by the amyloidogenic processing of the amyloid precursor protein (APP), culminating in the accumulation of amyloid-β peptides in the brain. The enzymatic action of the...
7.
Griffiths H, Whitehouse I, Baybutt H, Brown D, Kellett K, Jackson C, et al.
J Biol Chem
. 2011 Jul;
286(38):33489-500.
PMID: 21795680
In Alzheimer disease amyloid-β (Aβ) peptides derived from the amyloid precursor protein (APP) accumulate in the brain. Cleavage of APP by the β-secretase BACE1 is the rate-limiting step in the...
8.
Griffiths H, Morten I, Hooper N
Expert Opin Ther Targets
. 2008 May;
12(6):693-704.
PMID: 18479216
Background: The amyloid beta (Abeta) peptide is critical to the development of Alzheimer's disease (AD), the major neurodegenerative disease of the elderly for which there is currently no cure. Objective:...