Heinrich J G Matthies
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Explore the profile of Heinrich J G Matthies including associated specialties, affiliations and a list of published articles.
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26
Citations
799
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Recent Articles
1.
Shekar A, Mabry S, Cheng M, Aguilar J, Patel S, Zanella D, et al.
Sci Adv
. 2023 Jan;
9(2):eadd8417.
PMID: 36630507
Amphetamine (AMPH) is a psychostimulant that is commonly abused. The stimulant properties of AMPH are associated with its ability to increase dopamine (DA) neurotransmission. This increase is promoted by nonvesicular...
2.
DiCarlo G, Mabry S, Cao X, McMillan C, Woynaroski T, Harrison F, et al.
Front Psychiatry
. 2021 May;
12:655451.
PMID: 33935841
Altered dopamine (DA) signaling has been associated with autism spectrum disorder (ASD), a neurodevelopmental condition estimated to impact 1 in 54 children in the United States. There is growing evidence...
3.
Belovich A, Aguilar J, Mabry S, Cheng M, Zanella D, Hamilton P, et al.
Mol Psychiatry
. 2019 Dec;
26(8):4417-4430.
PMID: 31796894
Reward modulates the saliency of a specific drug exposure and is essential for the transition to addiction. Numerous human PET-fMRI studies establish a link between midbrain dopamine (DA) release, DA...
4.
Campbell N, Shekar A, Aguilar J, Peng D, Navratna V, Yang D, et al.
Proc Natl Acad Sci U S A
. 2019 Feb;
116(9):3853-3862.
PMID: 30755521
The human dopamine (DA) transporter (hDAT) mediates clearance of DA. Genetic variants in hDAT have been associated with DA dysfunction, a complication associated with several brain disorders, including autism spectrum...
5.
Shekar A, Aguilar J, Galli G, Cozzi N, Brandt S, Ruoho A, et al.
J Chem Neuroanat
. 2017 Feb;
83-84:69-74.
PMID: 28163218
Synthetic cathinones are similar in chemical structure to amphetamines, and their behavioral effects are associated with enhanced dopaminergic signaling. The past ten years of research on the common constituent of...
6.
Sodium-dependent vitamin C transporter-2 mediates vitamin C transport at the cortical nerve terminal
Pierce M, Raj A, Betke K, Zeidan L, Matthies H, May J
J Neurosci Res
. 2015 Sep;
93(12):1881-90.
PMID: 26366722
It has been shown that vitamin C (VC) is transported at synaptic boutons, but how this occurs has not been elucidated. This study investigates the role of the sodium-dependent vitamin...
7.
Dadalko O, Siuta M, Poe A, Erreger K, Matthies H, Niswender K, et al.
J Neurosci
. 2015 Jun;
35(23):8843-54.
PMID: 26063917
Disrupted neuronal protein kinase B (Akt) signaling has been associated with dopamine (DA)-related neuropsychiatric disorders, including schizophrenia, a devastating mental illness. We hypothesize that proper DA neurotransmission is therefore dependent...
8.
Cartier E, Hamilton P, Belovich A, Shekar A, Campbell N, Saunders C, et al.
EBioMedicine
. 2015 Mar;
2(2):135-146.
PMID: 25774383
Background: Syntaxin 1 (STX1) is a presynaptic plasma membrane protein that coordinates synaptic vesicle fusion. STX1 also regulates the function of neurotransmitter transporters, including the dopamine (DA) transporter (DAT). The...
9.
Hamilton P, Belovich A, Khelashvili G, Saunders C, Erreger K, Javitch J, et al.
Nat Chem Biol
. 2014 Jun;
10(7):582-589.
PMID: 24880859
Phosphatidylinositol (4,5)-bisphosphate (PIP2) regulates the function of ion channels and transporters. Here, we demonstrate that PIP2 directly binds the human dopamine (DA) transporter (hDAT), a key regulator of DA homeostasis...
10.
Saunders C, Siuta M, Robertson S, Davis A, Sauer J, Matthies H, et al.
Neurochem Int
. 2013 Oct;
73:113-121.
PMID: 24090638
The serotonergic system regulates a wide range of behavior, including mood and impulsivity, and its dysregulation has been associated with mood disorders, autism spectrum disorder, and addiction. Diabetes is a...