Hein F B M Sleddens
Overview
Explore the profile of Hein F B M Sleddens including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
16
Citations
444
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Meijer T, Verkaik N, van Deurzen C, Dubbink H, den Toom T, Sleddens H, et al.
JCO Precis Oncol
. 2022 Feb;
3:1-12.
PMID: 35100677
Purpose: Biomarkers that predict response to poly (ADP-ribose) polymerase inhibitors (PARPis) are required to detect PARPi sensitivity beyond germline -mutated (gBRCAm) cancers and PARPi resistance among reverted gBRCAm cancers. Therefore,...
2.
Radonic T, Geurts-Giele W, Samsom K, Roemen G, von der Thusen J, Thunnissen E, et al.
J Thorac Oncol
. 2021 Feb;
16(5):798-806.
PMID: 33588111
Introduction: RET gene fusions are established oncogenic drivers in 1% of NSCLC. Accurate detection of advanced patients with RET fusions is essential to ensure optimal therapy choice. We investigated the...
3.
den Bakker M, den Toom D, Damen T, Sleddens H, Meijssen I, Deloose S, et al.
Int J Surg Pathol
. 2020 May;
28(7):793-798.
PMID: 32362169
Anisometric cell lipoma (ACL) and dysplastic lipoma (DL) are underrecognized subtypes of benign lipomatous tumors, with wide variation in cell size, microscopic fat necrosis, and no or mild nuclear changes...
4.
Agahozo M, Timmermans M, Sleddens H, Foekens R, Trapman-Jansen A, Schroder C, et al.
Cancers (Basel)
. 2020 Mar;
12(3).
PMID: 32182822
Loss of Y-chromosome (LOY) is associated with increased cancer mortality in males. The prevalence of LOY in male breast cancer (BC) is unknown. The aim of this study is to...
5.
Somatic mutations and copy number variations in breast cancers with heterogeneous HER2 amplification
Van Bockstal M, Agahozo M, van Marion R, Atmodimedjo P, Sleddens H, Dinjens W, et al.
Mol Oncol
. 2020 Feb;
14(4):671-685.
PMID: 32058674
Intratumour heterogeneity fuels carcinogenesis and allows circumventing specific targeted therapies. HER2 gene amplification is associated with poor outcome in invasive breast cancer. Heterogeneous HER2 amplification has been described in 5-41%...
6.
Meijer T, Verkaik N, Sieuwerts A, van Riet J, Naipal K, van Deurzen C, et al.
Clin Cancer Res
. 2019 May;
25(9):2935.
PMID: 31043383
No abstract available.
7.
Agahozo M, Sieuwerts A, Doebar S, Verhoef E, Beaufort C, Ruigrok-Ritstier K, et al.
Endocr Relat Cancer
. 2019 Mar;
26(5):471-482.
PMID: 30844755
PIK3CA is one of the most frequently mutated genes in invasive breast cancer (IBC). These mutations are generally associated with hyper-activation of the phosphatidylinositol 3-kinase signaling pathway, which involves increased...
8.
Meijer T, Verkaik N, Sieuwerts A, van Riet J, Naipal K, van Deurzen C, et al.
Clin Cancer Res
. 2018 Aug;
24(24):6277-6287.
PMID: 30139880
Purpose: Tumors of germline mutated carriers show homologous recombination (HR) deficiency (HRD), resulting in impaired DNA double-strand break (DSB) repair and high sensitivity to PARP inhibitors. Although this therapy is...
9.
Ikpa P, Sleddens H, Steinbrecher K, Peppelenbosch M, De Jonge H, Smits R, et al.
Histochem Cell Biol
. 2016 Jun;
146(4):445-55.
PMID: 27246004
Guanylin (GN) and uroguanylin (UGN), through activation of guanylyl cyclase C (GCC), serve to control intestinal fluid homeostasis. Both peptides are produced in the intestinal epithelium, but their cellular origin...
10.
Verhoef E, Kolijn K, De Herdt M, van der Steen B, Hoogland A, Sleddens H, et al.
Oncotarget
. 2016 Apr;
7(21):31029-36.
PMID: 27105539
Tyrosine-kinase inhibitors of the hepatocyte growth factor receptor MET are under investigation for the treatment of hormone-refractory prostate cancer (HRPC) metastasis. Analysis of MET protein expression and genetic alterations might...