Heike Gielen-Haertwig
Overview
Explore the profile of Heike Gielen-Haertwig including associated specialties, affiliations and a list of published articles.
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5
Citations
135
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Recent Articles
1.
Vennemann M, Ruland V, Kruse J, Harloff C, Trubel H, Gielen-Haertwig H
Drug Discov Today
. 2019 Jun;
24(9):1924-1929.
PMID: 31233729
In pharmaceutical R&D the strategic focus is on addressing areas of high unmet medical need. 'Unmet medical need' is a widely used term in the healthcare sector but a common...
2.
von Nussbaum F, Li V, Allerheiligen S, Anlauf S, Barfacker L, Bechem M, et al.
ChemMedChem
. 2015 Jun;
10(7):1163-73.
PMID: 26083237
Human neutrophil elastase (HNE) is a key protease for matrix degradation. High HNE activity is observed in inflammatory diseases. Accordingly, HNE is a potential target for the treatment of pulmonary...
3.
Barfacker L, Kuhl A, Hillisch A, Grosser R, Figueroa-Perez S, Heckroth H, et al.
ChemMedChem
. 2012 Jul;
7(8):1385-403.
PMID: 22791416
Aldosterone is a hormone that exerts manifold deleterious effects on the kidneys, blood vessels, and heart which can lead to pathophysiological consequences. Inhibition of the mineralocorticoid receptor (MR) is a...
4.
Hansen G, Gielen-Haertwig H, Reinemer P, Schomburg D, Harrenga A, Niefind K
J Mol Biol
. 2011 May;
409(5):681-91.
PMID: 21549129
Human neutrophil elastase (HNE), a trypsin-type serine protease, is of pivotal importance in the onset and progression of chronic obstructive pulmonary disease (COPD). COPD encompasses a group of slowly progressive...
5.
Schmeck C, Gielen-Haertwig H, Vakalopoulos A, Bischoff H, Li V, Wirtz G, et al.
Bioorg Med Chem Lett
. 2010 Feb;
20(5):1740-3.
PMID: 20137927
In the course of our efforts to identify orally active cholesteryl ester transfer protein (CETP) inhibitors, we have continued to explore tetrahydrochinoline derivatives. Based on BAY 19-4789 structural modifications led...