Hee-Chul Ahn
Overview
Explore the profile of Hee-Chul Ahn including associated specialties, affiliations and a list of published articles.
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59
Citations
375
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Recent Articles
1.
Tran D, Nguyen H, Ahn H, Kim Y
Bioorg Med Chem
. 2024 Oct;
114:117963.
PMID: 39454562
The 3-helix is a crucial secondary structure in proteins, playing an essential role in various protein-protein interactions, yet stabilizing it in biologically relevant peptides remains challenging. In this study, we...
2.
Tak J, Nguyen T, Lee K, Kim S, Ahn H
Biomed Pharmacother
. 2024 Mar;
174:116459.
PMID: 38518599
Ubiquitin-specific protease (USP), an enzyme catalyzing protein deubiquitination, is involved in biological processes related to metabolic disorders and cancer proliferation. We focused on constructing predictive models tailored to unveil compounds...
3.
Hicks K, Cluntun A, Schubert H, Hackett S, Berg J, Leonard P, et al.
Science
. 2023 Mar;
379(6636):996-1003.
PMID: 36893255
Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated...
4.
Nguyen T, Phung H, Choi W, Ahn H
Plants (Basel)
. 2022 Dec;
11(24).
PMID: 36559697
Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease with limited treatment options. The widely distributed plant has shown protective effects against NASH in animals, yet the precise...
5.
Duong M, Ahn H
Pharmaceutics
. 2022 Sep;
14(9).
PMID: 36145648
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are related to cell proliferation, gene expression, and cell death. JNK isoform 3 (JNK3) is...
6.
Nguyen N, Duong M, Bui B, Nguyen P, Chen X, Cho J, et al.
Int J Mol Sci
. 2022 Sep;
23(18).
PMID: 36142500
Our structure-based virtual screening of the FDA-approved drug library has revealed that sonidegib, a smoothened antagonist clinically used to treat basal cell carcinoma, is a potential c-Jun N-terminal kinase 3...
7.
Eo Y, Duong M, Ahn H
Biomolecules
. 2022 Sep;
12(9).
PMID: 36139014
Malate dehydrogenase (MDH), which catalyzes a reversible conversion of -malate to oxaloacetate, plays essential roles in common metabolic processes, such as the tricarboxylic acid cycle, the oxaloacetate-malate shuttle, and the...
8.
Nguyen N, Duong M, Nguyen P, Bui B, Ahn H, Cho J
Biomol Ther (Seoul)
. 2022 Aug;
30(5):455-464.
PMID: 35993250
Efonidipine, a calcium channel blocker, is widely used for the treatment of hypertension and cardiovascular diseases. In our preliminary study using structure-based virtual screening, efonidipine was identified as a potential...
9.
Nguyen P, Bui B, Duong M, Lee K, Ahn H, Cho J
Int J Mol Sci
. 2021 Aug;
22(16).
PMID: 34445767
The c-Jun N-terminal kinases (JNKs) are implicated in many neuropathological conditions, including neurodegenerative diseases. To explore potential JNK3 inhibitors from the U.S. Food and Drug Administration-approved drug library, we performed...
10.
Do V, Seo Y, Park J, Yu J, Duong M, Nakai J, et al.
Arch Toxicol
. 2020 Oct;
95(2):541-556.
PMID: 33074372
Chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) are biocidal preservatives and the active ingredients in Kathon CG, which contains ca. 1.5% mixture of CMIT and MIT at a ratio of 3:1 (CMIT/MIT)....