Heba Alnakhala
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Explore the profile of Heba Alnakhala including associated specialties, affiliations and a list of published articles.
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9
Citations
21
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Recent Articles
1.
Elbatrawy A, Ademoye T, Alnakhala H, Tripathi A, Zhu X, Plascencia-Villa G, et al.
ACS Omega
. 2025 Mar;
10(7):6721-6734.
PMID: 40028124
Alzheimer's (AD) and Parkinson's (PD) disease are neurodegenerative disorders that are considered to be a significant global health challenge due to their increasing prevalence and profound impact on both individuals...
2.
Elbatrawy A, Ademoye T, Alnakhala H, Tripathi A, Plascencia-Villa G, Zhu X, et al.
Bioorg Med Chem
. 2024 Nov;
116:117990.
PMID: 39550891
Tau and α-synuclein (α-syn) are prone-to-aggregate proteins that can be responsible for pathological lesions found in the brains of Alzheimer's disease (AD), Lewy body dementia (LBD), and Parkinson's disease (PD)...
3.
Ganegamage S, Ademoye T, Patel H, Alnakhala H, Tripathi A, Nguyen C, et al.
ACS Chem Neurosci
. 2024 Oct;
15(21):3915-3931.
PMID: 39436010
Alzheimer's disease (AD) and Parkinson's disease (PD) are multifactorial, chronic diseases involving neurodegeneration. According to recent studies, it is hypothesized that the intraneuronal and postsynaptic accumulation of misfolded proteins such...
4.
Tripathi A, Alnakhala H, Brontesi L, Selkoe D, Dettmer U
Cell Mol Life Sci
. 2024 Aug;
81(1):362.
PMID: 39162859
Disease-modifying strategies for Parkinson disease (PD), the most common synucleinopathy, represent a critical unmet medical need. Accumulation of the neuronal protein alpha-synuclein (αS) and abnormal lipid metabolism have each been...
5.
Elbatrawy A, Ademoye T, Alnakhala H, Tripathi A, Zami A, Ostafe R, et al.
Bioorg Med Chem
. 2024 Feb;
100:117613.
PMID: 38330847
Tau and α-synuclein aggregates are the main histopathological hallmarks present in Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative disorders. Intraneuronal hyperphosphorylated tau accumulation is significantly connected to the...
6.
Ganegamage S, Ramirez E, Alnakhala H, Tripathi A, Nguyen C, Zami A, et al.
ACS Omega
. 2024 Jan;
9(1):1216-1229.
PMID: 38222653
Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting the elderly population worldwide. In PD, the misfolding of α-synuclein (α-syn) results in the formation of inclusions referred to...
7.
Shimanaka K, Shi B, Brontesi L, Alnakhala H, Jayanthi V, Subramanian K, et al.
FEBS Lett
. 2023 Nov;
598(2):210-219.
PMID: 37989349
The neuronal protein α-synuclein is centrally involved in the neurodegeneration occurring in Parkinson's disease and related synucleinopathies. α-Synuclein's membrane-induced 3-11 helix conformation has a hydrophobic membrane-embedded half and a hydrophilic...
8.
Ramirez E, Ganegamage S, Min S, Patel H, Ogunware A, Plascencia-Villa G, et al.
ACS Chem Neurosci
. 2023 Oct;
14(21):3913-3927.
PMID: 37818657
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder underlying dementia in the geriatric population. AD manifests by two pathological hallmarks: extracellular amyloid-β (Aβ) peptide-containing senile plaques and intraneuronal neurofibrillary...
9.
Ramirez E, Ganegamage S, Elbatrawy A, Alnakhala H, Shimanaka K, Tripathi A, et al.
ACS Omega
. 2023 Jun;
8(22):20102-20115.
PMID: 37305264
Protein misfolding results in a plethora of known diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, transthyretin-related amyloidosis, type 2 diabetes, Lewy body dementia, and spongiform encephalopathy. To provide...
10.
Tripathi A, Alnakhala H, Terry-Kantor E, Newman A, Liu L, Imberdis T, et al.
J Neurosci
. 2022 Jan;
42(10):2116-2130.
PMID: 35086904
α-Synuclein (αS) plays a key role in Parkinson's disease. Although Parkinson's disease is typically "sporadic," inherited αS missense mutations provide crucial insights into molecular mechanisms. Here, we examine two clinical...