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Heba Ali

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Articles 26
Citations 136
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Recent Articles
1.
AlSiraj Y, Ensor C, English V, Loria A, Ali H, Cassis L
J Pharmacol Exp Ther . 2025 Mar; 392(2):100533. PMID: 40023595
Serotonin (5-HT) has been implicated in cerebral aneurysm rupture, but it is unclear whether 5-HT plays a role in aortic aneurysm development and rupture, despite well known contractile effects of...
2.
Fadhul T, Park S, Ali H, AlSiraj Y, Wali J, Simpson S, et al.
Nutrients . 2025 Jan; 17(1. PMID: 39796558
High sugar intake, particularly fructose, is implicated in obesity and metabolic complications. On the other hand, fructose from fruits and vegetables has undisputed benefits for metabolic health. This raises a...
3.
Fadhul T, Park S, Ali H, AlSiraj Y, Wali J, Simpson S, et al.
bioRxiv . 2024 Dec; PMID: 39651130
Background/objectives: Numerous studies have implicated high intake of sugar, particularly fructose, with the development of obesity and metabolic complications. On the other hand, fructose from fruits and vegetables has undisputed...
4.
Liu Y, Zhou F, Ali H, Lathia J, Chen P
Cell Mol Immunol . 2024 Oct; 21(12):1354-1375. PMID: 39406966
Glioblastoma (GBM) is an aggressive and lethal type of brain tumor in human adults. The standard of care offers minimal clinical benefit, and most GBM patients experience tumor recurrence after...
5.
Liu Y, Wu J, Najem H, Lin Y, Pang L, Khan F, et al.
J Clin Invest . 2024 Oct; 134(22). PMID: 39352749
Tumor-associated macrophages and microglia (TAMs) are critical for tumor progression and therapy resistance in glioblastoma (GBM), a type of incurable brain cancer. We previously identified lysyl oxidase (LOX) and olfactomedin...
6.
Zeppillo T, Ali H, Ravichandran S, Ritter T, Wenger S, Lopez-Murcia F, et al.
Commun Biol . 2024 Sep; 7(1):1157. PMID: 39284869
Neuroligin-2 (Nlgn2) is a key synaptic adhesion protein at virtually all GABAergic synapses, which recruits GABARs by promoting assembly of the postsynaptic gephyrin scaffold. Intriguingly, loss of Nlgn2 differentially affects...
7.
Tohonen V, Antonson P, Boggavarapu N, Ali H, Motaholi L, Gustafsson J, et al.
F S Sci . 2024 Aug; 5(4):306-317. PMID: 39168303
Objective: To study the role of estrogen receptor β in follicle development and maturation and the response to gonadotropin stimulation aiming at superovulation. Design: Experimental study and transcriptomic analysis. Setting:...
8.
Pang L, Zhou F, Liu Y, Ali H, Khan F, Heimberger A, et al.
J Clin Invest . 2024 Aug; 134(12). PMID: 39133578
Although cancer has long been considered a genetic disease, increasing evidence shows that epigenetic aberrations play a crucial role in affecting tumor biology and therapeutic response. The dysregulated epigenome in...
9.
Liu Y, Ali H, Khan F, Pang L, Chen P
Trends Mol Med . 2024 Mar; 30(5):429-442. PMID: 38453529
Glioma is a type of aggressive and incurable brain tumor. Patients with glioma are highly resistant to all types of therapies, including immunotherapies. Epigenetic reprogramming is a key molecular hallmark...
10.
Khan F, Lin Y, Ali H, Pang L, Dunterman M, Hsu W, et al.
Nat Commun . 2024 Mar; 15(1):1987. PMID: 38443336
Abundant macrophage infiltration and altered tumor metabolism are two key hallmarks of glioblastoma. By screening a cluster of metabolic small-molecule compounds, we show that inhibiting glioblastoma cell glycolysis impairs macrophage...