Heather M A Prince
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Explore the profile of Heather M A Prince including associated specialties, affiliations and a list of published articles.
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17
Citations
457
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Recent Articles
1.
Gilliland W, White N, Yam B, Mwangi J, Prince H, Weideman A, et al.
Analyst
. 2020 May;
145(13):4540-4550.
PMID: 32420552
Analysis of drugs in hair by mass spectrometry imaging (MSI) has great potential as an objective, long-term measure of medication adherence. However, the fidelity of the chemical record in hair...
2.
Gilliland Jr W, Prince H, Poliseno A, Kashuba A, Rosen E
Anal Chem
. 2019 Jul;
91(16):10816-10822.
PMID: 31345022
Here, we assess infrared matrix assisted laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging (MSI) analysis of hair as a clinical tool for monitoring patient adherence to the antiretroviral maraviroc...
3.
Thompson C, Rosen E, Prince H, White N, Sykes C, De la Cruz G, et al.
Sci Transl Med
. 2019 Jul;
11(499).
PMID: 31270274
HIV replication within tissues may increase in response to a reduced exposure to antiretroviral drugs. Traditional approaches to measuring drug concentrations in tissues are unable to characterize a heterogeneous drug...
4.
Greene S, Chen J, Prince H, Sykes C, Schauer A, Blake K, et al.
Clin Pharmacol Ther
. 2019 Apr;
106(4):821-830.
PMID: 31002391
Understanding antiretroviral disposition in the male genital tract, a distinct viral compartment, can provide insight for the eradication of HIV. Population pharmacokinetic modeling was conducted to investigate the disposition of...
5.
Cottrell M, Prince H, Schauer A, Sykes C, Maffuid K, Poliseno A, et al.
Clin Infect Dis
. 2019 Apr;
69(12):2201-2204.
PMID: 30963179
Feminizing hormone therapy (FHT) may interact with human immunodeficiency virus preexposure prophylaxis (PrEP). We found that transgender women who took FHT exhibited a 7-fold lower rectal tissue ratio of PrEP's...
6.
Dumond J, Greene S, Prince H, Chen J, Maas B, Sykes C, et al.
Antivir Ther
. 2018 Oct;
24(1):45-50.
PMID: 30375984
Background: The male genital tract (MGT) is a viral sanctuary and likely HIV reservoir; understanding MGT pharmacokinetics (PK) of antiretrovirals (ARVs) used for curative strategies is critical to eradication and...
7.
Cottrell M, Garrett K, Prince H, Sykes C, Schauer A, Emerson C, et al.
J Antimicrob Chemother
. 2017 Apr;
72(6):1731-1740.
PMID: 28369415
Objectives: Tenofovir alafenamide, a prodrug of tenofovir, produces higher PBMC concentrations of tenofovir diphosphate (tenofovir-dp) than tenofovir disoproxil fumarate. To understand tenofovir alafenamide's mucosal tissue distribution and its implications for...
8.
Maas B, Francis O, Mollan K, Lee C, Cottrell M, Prince H, et al.
PLoS One
. 2016 Dec;
11(12):e0168709.
PMID: 28036343
Objectives: As the HIV-infected population ages, the role of cellular senescence and inflammation on co-morbid conditions and pharmacotherapy is increasingly of interest. p16INK4a expression, a marker for aging and senescence...
9.
Cottrell M, Prince H, Allmon A, Mollan K, Hudgens M, Sykes C, et al.
J Acquir Immune Defic Syndr
. 2016 Mar;
72(5):498-506.
PMID: 26999532
Background: Quantifying tissue drug concentrations can yield important information during drug development, but complicates pharmacokinetic study design. Mucosal fluids collected by direct aspiration (cervicovaginal fluid; CVF) or swab (rectal fluid;...
10.
Cottrell M, Yang K, Prince H, Sykes C, White N, Malone S, et al.
J Infect Dis
. 2016 Feb;
214(1):55-64.
PMID: 26917574
Background: A novel translational pharmacology investigation was conducted by combining an in vitro efficacy target with mucosal tissue pharmacokinetic (PK) data and mathematical modeling to determine the number of doses...