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Heather L Frericks Schmidt

Explore the profile of Heather L Frericks Schmidt including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 163
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Recent Articles
1.
Mehio N, Frericks Schmidt H, Wood G, Hancock B, Shanker R, Bartlett J, et al.
Int J Pharm . 2022 Jun; 623:121908. PMID: 35700869
Multiparticulate formulations allow for the design of specialized pharmaceutical dosage forms that cater to the needs of a wide range of patient demographics, such as pediatric and geriatric populations, by...
2.
Duggirala N, Frericks Schmidt H, Lei Z, Zaworotko M, Krzyzaniak J, Arora K
Mol Pharm . 2018 Apr; 15(5):1901-1908. PMID: 29659293
The current study integrates formation enthalpy and traditional slurry experiments to quickly assess the physical stability of cocrystal drug substance candidates for their potential to support drug development. Cocrystals of...
3.
Lin M, Sperling L, Frericks Schmidt H, Tang M, Samoilova R, Kumasaka T, et al.
Methods . 2011 Sep; 55(4):370-8. PMID: 21925267
Amino-acid selective isotope labeling of proteins offers numerous advantages in mechanistic studies by revealing structural and functional information unattainable from a crystallographic approach. However, efficient labeling of proteins with selected...
4.
Frericks Schmidt H, Shah G, Sperling L, Rienstra C
J Phys Chem Lett . 2010 Jun; 1(10):1623-1628. PMID: 20563223
Charged residues play an important role in defining key mechanistic features in many biomolecules. Determining the pK(a) values of large, membrane or fibrillar proteins can be challenging with traditional methods....
5.
Franks W, Wylie B, Frericks Schmidt H, Nieuwkoop A, Mayrhofer R, Shah G, et al.
Proc Natl Acad Sci U S A . 2008 Mar; 105(12):4621-6. PMID: 18344321
Magic-angle spinning (MAS) solid-state NMR (SSNMR) techniques have emerged in recent years for solving complete structures of uniformly labeled proteins lacking macroscopic order. Strategies used thus far have relied primarily...
6.
Frericks Schmidt H, Sperling L, Gao Y, Wylie B, Boettcher J, Wilson S, et al.
J Phys Chem B . 2007 Dec; 111(51):14362-9. PMID: 18052145
The study of micro- or nanocrystalline proteins by magic-angle spinning (MAS) solid-state NMR (SSNMR) gives atomic-resolution insight into structure in cases when single crystals cannot be obtained for diffraction studies....
7.
Rupasinghe S, Duan H, Frericks Schmidt H, Berthold D, Rienstra C, Schuler M
Biochim Biophys Acta . 2007 Nov; 1768(12):3061-70. PMID: 18005930
Cytochrome P450 monooxygenases (P450s), which represent the major group of drug metabolizing enzymes in humans, also catalyze important synthetic and detoxicative reactions in insects, plants and many microbes. Flexibilities in...