Heather L Caslin
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Explore the profile of Heather L Caslin including associated specialties, affiliations and a list of published articles.
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26
Citations
455
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Recent Articles
1.
Kohutek Z, Caslin H, Fehrenbach D, Heimlich J, Brown J, Madhur M, et al.
Circ Res
. 2025 Jan;
136(3):325-353.
PMID: 39883790
Cardiovascular and cardiometabolic diseases are leading causes of morbidity and mortality worldwide, driven in part by chronic inflammation. Emerging research suggests that the bone marrow microenvironment, or marrow niche, plays...
2.
Bolden M, Davis X, Sherwood E, Bohannon J, Caslin H
bioRxiv
. 2024 Aug;
PMID: 39211192
Different stimuli can induce innate immune memory to improve pathogen defense or worsen cardiometabolic disease. However, it is less clear if the same stimuli can induce both the protective and...
3.
Taruselli M, Abdul Qayum A, Abebayehu D, Caslin H, Dailey J, Kotha A, et al.
J Immunol
. 2024 Feb;
212(8):1277-1286.
PMID: 38381001
IL-33 is an inflammatory cytokine that promotes allergic disease by activating group 2 innate lymphoid cells, Th2 cells, and mast cells. IL-33 is increased in asthmatics, and its blockade suppresses...
4.
Caslin H, Bolus W, Thomas C, Toki S, Norlander A, Peebles Jr R, et al.
Immunohorizons
. 2023 Dec;
7(12):842-852.
PMID: 38095595
All cells of the immune system reside in adipose tissue (AT), and increasing type 2 immune cells may be a therapeutic strategy to improve metabolic health. In our previous study...
5.
Caslin H, Cottam M, Betjemann A, Mashayekhi M, Silver H, Hasty A
bioRxiv
. 2023 Nov;
PMID: 38014269
Our recent study showed weight cycled mice have increased adipose mast cells compared to obese mice by single cell RNA-sequencing. Here, we aimed to confirm and elucidate these changes. Further...
6.
Schleh M, Caslin H, Garcia J, Mashayekhi M, Srivastava G, Bradley A, et al.
Sci Transl Med
. 2023 Nov;
15(723):eadf9382.
PMID: 37992150
Obesity-associated inflammation is a systemic process that affects all metabolic organs. Prominent among these is adipose tissue, where cells of the innate and adaptive immune system are markedly changed in...
7.
Caslin H, Cottam M, Pinon J, Boney L, Hasty A
Front Immunol
. 2023 Jan;
13:984859.
PMID: 36713396
Introduction: Weight loss improves obesity-associated diabetes risk. However, most individuals regain weight, which worsens the risk of developing diabetes and cardiovascular disease. We previously reported that male mice retain obesity-associated...
8.
Blanks A, Pedersen L, Caslin H, Mihalick V, Via J, Canada J, et al.
Diabetes Res Clin Pract
. 2022 Sep;
191:110077.
PMID: 36089102
Aims: Following ST-segment elevation myocardial infarction (STEMI), recruitment and activation of monocytes [classical (CD14CD16CCR2), intermediate (CD14CD16CCR2), non-classical (CD14CD16CCR2)] are needed for myocardial wound healing. Monocyte surface receptor CC chemokine receptor...
9.
Winn N, Cottam M, Bhanot M, Caslin H, Garcia J, Arrojo E Drigo R, et al.
Diabetes
. 2022 Jul;
71(11):2313-2330.
PMID: 35802127
In the setting of obesity and insulin resistance, glycemia is controlled in part by β-cell compensation and subsequent hyperinsulinemia. Weight loss improves glycemia and decreases hyperinsulinemia, whereas weight cycling worsens...
10.
Cottam M, Caslin H, Winn N, Hasty A
Nat Commun
. 2022 May;
13(1):2950.
PMID: 35618862
Within adipose tissue (AT), immune cells and parenchymal cells closely interact creating a complex microenvironment. In obesity, immune cell derived inflammation contributes to insulin resistance and glucose intolerance. Diet-induced weight...