He-Jin Lee
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Explore the profile of He-Jin Lee including associated specialties, affiliations and a list of published articles.
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55
Citations
9339
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Recent Articles
1.
Kim T, Bae E, Jung B, Choi M, Shin S, Park S, et al.
Exp Mol Med
. 2024 Mar;
56(4):1029-1030.
PMID: 38556555
No abstract available.
2.
Lee H, Yoon Y, Lee S
J Mol Biol
. 2023 Apr;
435(12):168114.
PMID: 37085010
Neurodegenerative diseases, such as Alzheimer's and Parkinson's, are characterized by several pathological features, including selective neuronal loss, aggregation of specific proteins, and chronic inflammation. Aging is the most critical risk...
3.
Kim T, Bae E, Jung B, Choi M, Shin S, Park S, et al.
Exp Mol Med
. 2022 Dec;
54(12):2148-2161.
PMID: 36473937
The clinical progression of neurodegenerative diseases correlates with the spread of proteinopathy in the brain. The current understanding of the mechanism of proteinopathy spread is far from complete. Here, we...
4.
Yoon Y, You J, Kim T, Ahn W, Kim M, Son K, et al.
Exp Mol Med
. 2022 Feb;
54(2):115-128.
PMID: 35136202
α-Synuclein is a crucial element in the pathogenesis of Parkinson's disease (PD) and related neurological diseases. Although numerous studies have presented potential mechanisms underlying its pathogenesis, the understanding of α-synuclein-mediated...
5.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
6.
Yoon Y, Ahn W, Ricarte D, Ortiz D, Shin C, Lee S, et al.
Biomol Ther (Seoul)
. 2020 Jun;
29(1):83-89.
PMID: 32536617
Multiple system atrophy (MSA) is a neurodegenerative disease characterized by presence of α-synuclein-positive inclusions in the cytoplasm of oligodendrocytes. These glial cytoplasmic inclusions (GCIs) are considered an integral part of...
7.
Lee H, Ricarte D, Ortiz D, Lee S
Exp Mol Med
. 2019 Nov;
51(11):1-10.
PMID: 31740682
Multiple system atrophy (MSA) is a neurodegenerative disease with diverse clinical manifestations, including parkinsonism, cerebellar syndrome, and autonomic failure. Pathologically, MSA is characterized by glial cytoplasmic inclusions in oligodendrocytes, which...
8.
Lee J, Kanai K, Suzuki M, Kim W, Yoo H, Fu Y, et al.
Brain
. 2019 Jul;
142(9):2845-2859.
PMID: 31312839
Mutations in lysosomal genes increase the risk of neurodegenerative diseases, as is the case for Parkinson's disease. Here, we found that pathogenic and protective mutations in arylsulfatase A (ARSA), a...
9.
Bae E, Kim D, Kim C, Mante M, Adame A, Rockenstein E, et al.
Nat Commun
. 2018 Aug;
9(1):3465.
PMID: 30150626
Propagation of α-synuclein aggregates has been suggested as a contributing factor in Parkinson's disease (PD) progression. However, the molecular mechanisms underlying α-synuclein aggregation are not fully understood. Here, we demonstrate...
10.
Kim C, Spencer B, Rockenstein E, Yamakado H, Mante M, Adame A, et al.
Mol Neurodegener
. 2018 Aug;
13(1):43.
PMID: 30092810
Background: Synucleinopathies of the aging population are an heterogeneous group of neurological disorders that includes Parkinson's disease (PD) and dementia with Lewy bodies (DLB) and are characterized by the progressive...