Hazem E Ghoneim
Overview
Explore the profile of Hazem E Ghoneim including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
2003
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Recent Articles
11.
LeMessurier K, Rooney R, Ghoneim H, Liu B, Li K, Smallwood H, et al.
J Leukoc Biol
. 2020 May;
108(1):151-168.
PMID: 32386457
Allergic asthma and influenza are common respiratory diseases with a high probability of co-occurrence. During the 2009 influenza pandemic, hospitalized patients with influenza experienced lower morbidity if asthma was an...
12.
Abdelsamed H, Zebley C, Nguyen H, Rutishauser R, Fan Y, Ghoneim H, et al.
Nat Immunol
. 2020 Apr;
21(5):578-587.
PMID: 32231298
The pool of beta cell-specific CD8 T cells in type 1 diabetes (T1D) sustains an autoreactive potential despite having access to a constant source of antigen. To investigate the long-lived...
13.
Fonseca R, Beura L, Quarnstrom C, Ghoneim H, Fan Y, Zebley C, et al.
Nat Immunol
. 2020 Feb;
21(4):412-421.
PMID: 32066954
Central memory T (T) cells patrol lymph nodes and perform conventional memory responses on restimulation: proliferation, migration and differentiation into diverse T cell subsets while also self-renewing. Resident memory T...
14.
Alfei F, Kanev K, Hofmann M, Wu M, Ghoneim H, Roelli P, et al.
Nature
. 2019 Jun;
571(7764):265-269.
PMID: 31207605
Cytotoxic T cells are essential mediators of protective immunity to viral infection and malignant tumours and are a key target of immunotherapy approaches. However, prolonged exposure to cognate antigens often...
15.
Youngblood B, Hale J, Kissick H, Ahn E, Xu X, Wieland A, et al.
Nature
. 2017 Dec;
552(7685):404-409.
PMID: 29236683
Memory CD8 T cells that circulate in the blood and are present in lymphoid organs are an essential component of long-lived T cell immunity. These memory CD8 T cells remain...
16.
Ghoneim H, Fan Y, Moustaki A, Abdelsamed H, Dash P, Dogra P, et al.
Cell
. 2017 Jun;
170(1):142-157.e19.
PMID: 28648661
Immune-checkpoint-blockade (ICB)-mediated rejuvenation of exhausted T cells has emerged as a promising approach for treating various cancers and chronic infections. However, T cells that become fully exhausted during prolonged antigen...
17.
Abdelsamed H, Moustaki A, Fan Y, Dogra P, Ghoneim H, Zebley C, et al.
J Exp Med
. 2017 May;
214(6):1593-1606.
PMID: 28490440
Antigen-independent homeostasis of memory CD8 T cells is vital for sustaining long-lived T cell-mediated immunity. In this study, we report that maintenance of human memory CD8 T cell effector potential...
18.
Ghoneim H, Zamora A, Thomas P, Youngblood B
Trends Mol Med
. 2016 Nov;
22(12):1000-1011.
PMID: 27825667
Prolonged exposure of CD8 T cells to their cognate antigen can result in exhaustion of effector functions enabling the persistence of infected or transformed cells. Recent advances in strategies to...
19.
Dogra P, Ghoneim H, Abdelsamed H, Youngblood B
Eur J Immunol
. 2016 May;
46(7):1548-62.
PMID: 27230488
T-cell-based immunological memory has the potential to provide the host with life-long protection against pathogen reexposure and thus offers tremendous promise for the design of vaccines targeting chronic infections or...
20.
Ghoneim H, McCullers J
J Infect Dis
. 2013 Nov;
209(9):1459-68.
PMID: 24273183
Secondary bacterial pneumonia is a significant cause of morbidity and mortality during influenza, despite routine use of standard antibiotics. Antibiotic-induced immunopathology associated with bacterial cell wall lysis has been suggested...