Hayley L Eames
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Explore the profile of Hayley L Eames including associated specialties, affiliations and a list of published articles.
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11
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479
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Recent Articles
1.
Zec K, Schonfeldova B, Ai Z, van Grinsven E, Pirgova G, Eames H, et al.
J Exp Med
. 2023 Apr;
220(8).
PMID: 37115585
The first immune-activating changes within joint resident cells that lead to pathogenic leukocyte recruitment during articular inflammation remain largely unknown. In this study, we employ state-of-the-art confocal microscopy and image...
2.
Ryzhakov G, Almuttaqi H, Corbin A, Berthold D, Khoyratty T, Eames H, et al.
Nat Commun
. 2021 Nov;
12(1):6702.
PMID: 34795257
Interferon regulating factor 5 (IRF5) is a multifunctional regulator of immune responses, and has a key pathogenic function in gut inflammation, but how IRF5 is modulated is still unclear. Having...
3.
Khoyratty T, Ai Z, Ballesteros I, Eames H, Mathie S, Martin-Salamanca S, et al.
Nat Immunol
. 2021 Jul;
22(9):1093-1106.
PMID: 34282331
Neutrophils display distinct gene expression patters depending on their developmental stage, activation state and tissue microenvironment. To determine the transcription factor networks that shape these responses in a mouse model,...
4.
Wang L, Ai Z, Khoyratty T, Zec K, Eames H, van Grinsven E, et al.
JCI Insight
. 2020 Sep;
5(20).
PMID: 32960815
Giant cell arteritis (GCA) is a common form of primary systemic vasculitis in adults, with no reliable indicators of prognosis or treatment responses. We used single cell technologies to comprehensively...
5.
Bo M, Niegowska M, Eames H, Almuttaqi H, Arru G, Erre G, et al.
J Transl Autoimmun
. 2020 Aug;
3:100048.
PMID: 32743529
Background: Improved knowledge of different biomarkers is crucial for early diagnosis of rheumatic diseases and to provide important insights for clinical management. In this study, we evaluated the seroreactivity of...
6.
Mathie S, Corbin A, Eames H, Udalova I
Methods Mol Biol
. 2018 Feb;
1745:113-124.
PMID: 29476466
Flow cytometry is extensively used for the immune-profiling of leukocytes in tissue during homeostasis and inflammation. The multiparametric power of using fluorescently conjugated antibodies for specific surface and activation markers...
7.
Eames H, Corbin A, Udalova I
Transl Res
. 2015 Jul;
167(1):167-82.
PMID: 26207886
Interferon regulatory factor 5 (IRF5) has been demonstrated as a key transcription factor of the immune system, playing important roles in modulating inflammatory immune responses in numerous cell types including...
8.
Blazek K, Eames H, Weiss M, Byrne A, Perocheau D, Pease J, et al.
J Exp Med
. 2015 May;
212(6):845-53.
PMID: 25941255
The most studied biological role of type III interferons (IFNs) has so far been their antiviral activity, but their role in autoimmune and inflammatory diseases remains largely unexplored. Here, we...
9.
Dalmas E, Toubal A, Alzaid F, Blazek K, Eames H, Lebozec K, et al.
Nat Med
. 2015 May;
21(6):610-8.
PMID: 25939064
Accumulation of visceral adipose tissue correlates with elevated inflammation and increased risk of metabolic diseases. However, little is known about the molecular mechanisms that control its pathological expansion. Transcription factor...
10.
Ryzhakov G, Eames H, Udalova I
J Interferon Cytokine Res
. 2014 Sep;
35(2):71-8.
PMID: 25259415
Interferon regulatory factor 5 (IRF5) is a crucial transcription factor in a number of immune and homeostatic processes, including host defense against pathogens, tumorigenesis, and autoimmunity. Upon induction of immune...