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Hay-Yan J Wang

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Articles 27
Citations 605
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Recent Articles
1.
Huang C, Tsai P, Wu H, Chen I, Wang H
Metabolites . 2022 Nov; 12(11). PMID: 36355158
Prior MALDI mass spectrometry imaging (MALDI-MSI) studies reported significant changes in phosphatidylcholines (PCs), lysophosphatidylcholines (LPCs), and sphingomyelins (SMs) in ischemic rat brains yet overlooked the information on other classes of...
2.
Wang H, Huang C, Wei K, Hung K
J Lipid Res . 2022 Oct; 63(12):100304. PMID: 36273646
Lipids perform multiple biological functions and reflect the physiology and pathology of cells, tissues, and organs. Here, we sought to understand lipid content in relation to tumor pathology by characterizing...
3.
Wang H, Hsu F
Anal Bioanal Chem . 2022 Jan; 414(6):2089-2102. PMID: 35013808
Phospholipids (PLs) and sphingolipids (SLs) perform critical structural and biological functions in cells. The structure of these lipids, including the stereospecificity and double-bond position of fatty acyl (FA) chains, is...
4.
Wang H
Methods Mol Biol . 2021 May; 2306:299-311. PMID: 33954955
Matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) of lipids is considered one of the shotgun lipidomic techniques that explores the in situ distribution of lipids in tissue sections. To successfully perform...
5.
Wang H, Tatituri R, Goldner N, Dantas G, Hsu F
Biochimie . 2020 Jul; 178:158-169. PMID: 32659445
Uncommon lipids in biotechnologically important Corynebacterium glutamicum and pathogen Corynebacterium striatum in genus Corynebacterium are isolated and identified by linear ion-trap multiple stage mass spectrometry (LIT MS) with high resolution...
6.
Wang H, Hsu F
J Am Soc Mass Spectrom . 2020 Mar; 31(5):1047-1057. PMID: 32167298
Fatty acyl coenzyme A esters (FA-CoAs) are important crossroad intermediates in lipid catabolism and anabolism, and the structures are complicated. Several mass spectrometric approaches have been previously described to elucidate...
7.
Wang H, Wu H, Tsai P, Liu C, Zheng Z
Anal Bioanal Chem . 2013 Dec; 406(2):565-75. PMID: 24317517
Cardiolipin (CL) is a class of phospholipid tightly associated with the mitochondria functions and a prime target of oxidative stress. Peroxidation of CL dissociates its bound cytochrome C, a phenomenon...
8.
Wang Y, Wang H, Liao Y, Tsai P, Chen K, Cheng H, et al.
Cardiovasc Res . 2012 Jul; 95(4):517-26. PMID: 22802111
Aims: Proliferation and migration of vascular smooth muscle cells (VSMCs) can cause atherosclerosis and neointimal formation. MicroRNAs have been shown to regulate cell proliferation and phenotype transformation. We discovered abundant...
9.
Wang H, Wu H, Tsai P, Liu C
Anal Bioanal Chem . 2012 May; 404(1):113-24. PMID: 22610601
Ischemia-mediated lipidomic changes in rat brains were explored by matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) profiling and imaging after in situ desalting which drastically simplified the spectral presentation of tissue lipids....
10.
Wang H, Liu C, Wu H
J Lipid Res . 2011 Jan; 52(4):840-9. PMID: 21266365
Direct MALDI-mass spectrometry (MALDI-MS) profiling of tissue lipids often observes isobaric phosphatidylcholine (PC) species caused by the endogenous alkali metal ions that bias the relative abundance of tissue lipids. Fresh...