Hasini A Kalpage
Overview
Explore the profile of Hasini A Kalpage including associated specialties, affiliations and a list of published articles.
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14
Citations
418
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Recent Articles
1.
Morse P, Wan J, Arroum T, Herroon M, Kalpage H, Bazylianska V, et al.
Biomolecules
. 2024 Jun;
14(6).
PMID: 38927098
Cytochrome (Cyt) is important for both mitochondrial respiration and apoptosis, both of which are altered in cancer cells that switch to Warburg metabolism and manage to evade apoptosis. We earlier...
2.
Morse P, Perez-Mejias G, Wan J, Turner A, Marquez I, Kalpage H, et al.
Nat Commun
. 2023 Jul;
14(1):4166.
PMID: 37443314
Skeletal muscle is more resilient to ischemia-reperfusion injury than other organs. Tissue specific post-translational modifications of cytochrome c (Cytc) are involved in ischemia-reperfusion injury by regulating mitochondrial respiration and apoptosis....
3.
Hege Hurrish K, Qiao X, Li X, Su Y, Carter J, Ma J, et al.
Biochem Pharmacol
. 2022 Oct;
205:115283.
PMID: 36208684
Despite the recently approved new therapies, the clinical outcomes of acute myeloid leukemia (AML) patients remain disappointing, highlighting the need for novel therapies. Our lab has previously demonstrated the promising...
4.
LaMoia T, Butrico G, Kalpage H, Goedeke L, Hubbard B, Vatner D, et al.
Proc Natl Acad Sci U S A
. 2022 Mar;
119(10):e2122287119.
PMID: 35238637
SignificanceMetformin is the most commonly prescribed drug for the treatment of type 2 diabetes mellitus, yet the mechanism by which it lowers plasma glucose concentrations has remained elusive. Most studies...
5.
Bazylianska V, Kalpage H, Wan J, Vaishnav A, Mahapatra G, Turner A, et al.
Cells
. 2021 Apr;
10(4).
PMID: 33916826
Prostate cancer is the second leading cause of cancer-related death in men. Two classic cancer hallmarks are a metabolic switch from oxidative phosphorylation (OxPhos) to glycolysis, known as the Warburg...
6.
Carter J, Hege K, Yang J, Kalpage H, Su Y, Edwards H, et al.
Signal Transduct Target Ther
. 2020 Dec;
5(1):288.
PMID: 33335095
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the second most common form of acute leukemia in children. Despite this, very little improvement...
7.
Carter J, Hege K, Kalpage H, Edwards H, Huttemann M, Taub J, et al.
Biochem Pharmacol
. 2020 Oct;
182:114253.
PMID: 33011159
Acute myeloid leukemia (AML) is a heterogeneous disease with variable presentation, molecular phenotype, and cytogenetic abnormalities and has seen very little improvement in patient survival over the last few decades....
8.
Liu F, Kalpage H, Wang D, Edwards H, Huttemann M, Ma J, et al.
Cancers (Basel)
. 2020 Aug;
12(9).
PMID: 32847115
Targeting oxidative phosphorylation (OXPHOS) is a promising strategy to improve treatment outcomes of acute myeloid leukemia (AML) patients. IACS-010759 is a mitochondrial complex I inhibitor that has demonstrated preclinical antileukemic...
9.
Kalpage H, Wan J, Morse P, Lee I, Huttemann M
Cells
. 2020 Aug;
9(8).
PMID: 32781572
We previously reported that serine-47 (S47) phosphorylation of cytochrome (Cyt) in the brain results in lower cytochrome oxidase (COX) activity and caspase-3 activity in vitro. We here analyze the effect...
10.
Kalpage H, Wan J, Morse P, Zurek M, Turner A, Khobeir A, et al.
Int J Biochem Cell Biol
. 2020 Feb;
121:105704.
PMID: 32023432
Cytochrome c (Cytc)is a cellular life and death decision molecule that regulates cellular energy supply and apoptosis through tissue specific post-translational modifications. Cytc is an electron carrier in the mitochondrial...