Haruko Sakai
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Explore the profile of Haruko Sakai including associated specialties, affiliations and a list of published articles.
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10
Citations
182
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Recent Articles
1.
Asakura K, Haga M, Adachi M, Sakai H, Takahashi C, Sasaki S
J Nutr Sci Vitaminol (Tokyo)
. 2015 Apr;
60(6):387-96.
PMID: 25866301
No study has documented Japanese children's food portion sizes. Since this information is essential to establish valid measurement tools and effective education methods for dietary intake, we measured them using...
2.
Nakajima M, Koga T, Sakai H, Yamanaka H, Fujiwara R, Yokoi T
Biochem Pharmacol
. 2009 Dec;
79(8):1165-72.
PMID: 19951703
UDP-glucuronosyltransferases (UGTs) catalyze the glucuronidation of a variety of xeno/endobiotics. UGTs are type I membrane proteins of the endoplasmic reticulum (ER) with a glycosylated luminal domain. In the present study,...
3.
Fukami T, Nakajima M, Sakai H, Katoh M, Yokoi T
Drug Metab Dispos
. 2006 Dec;
35(3):335-9.
PMID: 17178771
Human cytochrome CYP2A13 shows overlapping substrate specificity with CYP2A6, catalyzing the metabolism of coumarin, nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Recently, it was found that CYP2A13 could catalyze the metabolic activations of...
4.
Nakajima M, Itoh M, Sakai H, Fukami T, Katoh M, Yamazaki H, et al.
Int J Cancer
. 2006 Sep;
119(11):2520-6.
PMID: 16988941
Cigarette smoking is the predominant risk factor for bladder cancer. Aromatic amines such as 4-aminobiphenyl (ABP) is the major carcinogens found in tobacco smoke. Although it is generally accepted that...
5.
Nakajima M, Fukami T, Yamanaka H, Higashi E, Sakai H, Yoshida R, et al.
Clin Pharmacol Ther
. 2006 Sep;
80(3):282-97.
PMID: 16952495
Human cytochrome P450 (CYP) 2A6 metabolizes nicotine to cotinine and is a possible modulator of nicotine addiction. Quantitative and qualitative differences in nicotine addiction have been observed between ethnic groups....
6.
Nakano Y, Yamauchi A, Yano T, Nakayama O, Sakai H, Nagasaka Y, et al.
Jpn J Infect Dis
. 2006 Apr;
59(2):136-8.
PMID: 16632919
No abstract available.
7.
Sugiyama A, Iwade Y, Akachi S, Nakano Y, Matsuno Y, Yano T, et al.
Jpn J Infect Dis
. 2005 Dec;
58(6):398-400.
PMID: 16377881
No abstract available.
8.
Yamanaka H, Nakajima M, Fukami T, Sakai H, Nakamura A, Katoh M, et al.
Drug Metab Dispos
. 2005 Sep;
33(12):1811-8.
PMID: 16135656
Nornicotine is an N-demethylated metabolite of nicotine. In the present study, human cytochrome P450 (P450) isoform(s) involved in nicotine N-demethylation were identified. The Eadie-Hofstee plot of nicotine N-demethylation in human...
9.
Fukami T, Nakajima M, Higashi E, Yamanaka H, Sakai H, McLeod H, et al.
Drug Metab Dispos
. 2005 May;
33(8):1202-10.
PMID: 15900015
Genetic polymorphisms of CYP2A6 gene are known as a causal factor of the interindividual differences in nicotine metabolism. We found three novel CYP2A6 alleles. The CYP2A6(*)18A allele has a single...
10.
Kawasaki H, Hori H, Higashigawa M, Ido M, Sakai H, Komada Y, et al.
Am J Ther
. 1996 Aug;
3(8):563-567.
PMID: 11862291
Pretreatment of IL-3 to Kasumi-1 human acute myeloid leukemia cells enhanced 1-B-D-arabinofuranosyl cytosine (ara-C) cytotoxicity 1.2. to 1.4-fold (median 1.3). To clarify the mechanism of interleukin-3 (IL-3) on ara-C cytotoxicity,...