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Harsh Dweep

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Articles 38
Citations 2656
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Recent Articles
11.
Adeniji O, Giron L, Purwar M, Zilberstein N, Kulkarni A, Shaikh M, et al.
mBio . 2021 Apr; 12(2). PMID: 33879594
Beyond neutralization, antibodies binding to their Fc receptors elicit several innate immune functions including antibody-dependent complement deposition (ADCD), antibody-dependent cell-mediated phagocytosis (ADCP), and antibody-dependent cell-mediated cytotoxicity (ADCC). These functions are...
12.
Veglia F, Hashimoto A, Dweep H, Sanseviero E, De Leo A, Tcyganov E, et al.
J Exp Med . 2021 Feb; 218(4). PMID: 33566112
In this study, using single-cell RNA-seq, cell mass spectrometry, flow cytometry, and functional analysis, we characterized the heterogeneity of polymorphonuclear neutrophils (PMNs) in cancer. We describe three populations of PMNs...
13.
Somasundaram R, Connelly T, Choi R, Choi H, Samarkina A, Li L, et al.
Nat Commun . 2021 Jan; 12(1):346. PMID: 33436641
Anti-PD-1 therapy is used as a front-line treatment for many cancers, but mechanistic insight into this therapy resistance is still lacking. Here we generate a humanized (Hu)-mouse melanoma model by...
14.
Colomb F, Giron L, Kuri-Cervantes L, Adeniji O, Ma T, Dweep H, et al.
Cell Rep . 2020 Aug; 32(5):107991. PMID: 32755584
A comprehensive understanding of the phenotype of persistent HIV-infected cells, transcriptionally active and/or transcriptionally inactive, is imperative for developing a cure. The relevance of cell-surface glycosylation to HIV persistence has...
15.
Christofides A, Papagregoriou G, Dweep H, Makrides N, Gretz N, Felekkis K, et al.
Cell Mol Life Sci . 2019 Sep; 77(12):2441-2459. PMID: 31531679
Podocytes are highly differentiated epithelial cells outlining the glomerular vessels. FOXC2 is a transcription factor essential for inducing podocyte differentiation, development and maturation, and is considered to be the earliest...
16.
McCullough S, Dweep H, McGill M, Bhattacharyya S, James L, Frankowski S, et al.
Microrna . 2019 Aug; 9(2):121-132. PMID: 31393259
Background And Aim: Hepatic phase I drug-metabolizing enzymes CYP2E1, CYP1A2 and CYP3A4 catalyze the biotransformation of Acetaminophen (APAP) and are important in the mediation of toxicity. The potential role of...
17.
Schleimann M, Kobbero M, Vibholm L, Kjaer K, Giron L, Busman-Sahay K, et al.
EBioMedicine . 2019 Jul; 45:328-340. PMID: 31300344
Background: TLR9 agonists are being developed as immunotherapy against malignancies and infections. TLR9 is primarily expressed in B cells and plasmacytoid dendritic cells (pDCs). TLR9 signalling may be critically important...
18.
Voskarides K, Dweep H, Chrysostomou C
Hum Genomics . 2019 Jul; 13(1):29. PMID: 31266543
In the original publication of this article [1], the Figure 1 and Figure 2 were wrong. The Figure 1 "Heat map showing the quantity of DNA repair genes, from red...
19.
Voskarides K, Dweep H, Chrysostomou C
Hum Genomics . 2019 Jun; 13(1):26. PMID: 31174607
Adaptive radiation and evolutionary stasis are characterized by very different evolution rates. The main aim of this study was to investigate if any genes have a special role to a...
20.
Wohlfarth C, Schmitteckert S, Hartle J, Houghton L, Dweep H, Fortea M, et al.
Sci Rep . 2017 Nov; 7(1):14680. PMID: 29089619
Irritable bowel syndrome (IBS) is a gut-brain disorder involving alterations in intestinal sensitivity and motility. Serotonin 5-HT receptors are promising candidates in IBS pathophysiology since they regulate gut motor function...