Harry A T Pritchard
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Explore the profile of Harry A T Pritchard including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
326
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Recent Articles
1.
Evans L, Gray A, Walsh K, Danby T, Pritchard H, Allan S, et al.
Microcirculation
. 2025 Jan;
32(1):e70001.
PMID: 39777814
Objective: Cerebral blood flow (CBF) decline is increasingly recognized as an area of importance for targeting neurodegenerative disorders, yet full understanding of the mechanisms that underlie CBF changes are lacking....
2.
Rognant S, Baldwin S, Pritchard H, Greenstein A, Calloe K, Aalkjaer C, et al.
FASEB J
. 2023 Nov;
37(12):e23282.
PMID: 37994700
Prorenin and the prorenin receptor ((P)RR) are important, yet controversial, members of the renin-angiotensin-aldosterone system. The ((P)RR) is expressed throughout the body, including the vasculature, however, the direct effect of...
3.
Sri S, Greenstein A, Granata A, Collcutt A, Jochems A, McColl B, et al.
Cereb Circ Cogn Behav
. 2023 Nov;
5():100189.
PMID: 37941765
Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain...
4.
Taylor J, Walsh K, Mosneag I, Danby T, Luka N, Chanda B, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(33):e2307513120.
PMID: 37549299
The deficit in cerebral blood flow (CBF) seen in patients with hypertension-induced vascular dementia is increasingly viewed as a therapeutic target for disease-modifying therapy. Progress is limited, however, due to...
5.
Taylor J, Pritchard H, Walsh K, Strangward P, White C, Hill-Eubanks D, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(26):e2204581119.
PMID: 35727988
The brain microcirculation is increasingly viewed as a potential target for disease-modifying drugs in the treatment of Alzheimer's disease patients, reflecting a growing appreciation of evidence that cerebral blood flow...
6.
Evans L, Taylor J, Smith C, Pritchard H, Greenstein A, Allan S
Cardiovasc Res
. 2021 Sep;
117(13):2575-2588.
PMID: 34499123
Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive impairment and affects all levels of the brain's vasculature. Features include diverse structural and functional changes affecting...
7.
Worton S, Pritchard H, Greenwood S, Alakrawi M, Heazell A, Wareing M, et al.
Circ Res
. 2021 Mar;
128(11):1679-1693.
PMID: 33656370
[Figure: see text].
8.
Thakore P, Pritchard H, Griffin C, Yamasaki E, Drumm B, Lane C, et al.
Sci Signal
. 2020 Jun;
13(637).
PMID: 32576680
TRPML1 (transient receptor potential mucolipin 1) is a Ca-permeable, nonselective cation channel localized to the membranes of endosomes and lysosomes and is not present or functional on the plasma membrane....
9.
Pritchard H, Griffin C, Yamasaki E, Thakore P, Lane C, Greenstein A, et al.
Proc Natl Acad Sci U S A
. 2019 Oct;
116(43):21874-21881.
PMID: 31591206
Junctophilin proteins maintain close contacts between the endoplasmic/sarcoplasmic reticulum (ER/SR) and the plasma membrane in many types of cells, as typified by junctophilin-2 (JPH2), which is necessary for the formation...
10.
Pritchard H, Pires P, Yamasaki E, Thakore P, Earley S
Proc Natl Acad Sci U S A
. 2018 Sep;
115(41):E9745-E9752.
PMID: 30181262
Duchenne muscular dystrophy (DMD) results from mutations in the gene encoding dystrophin which lead to impaired function of skeletal and cardiac muscle, but little is known about the effects of...