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Harold M Aukema

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Articles 108
Citations 1370
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Recent Articles
1.
Kaur R, Kobue-Lekalake R, Masisi K, Aukema H, Moghadasian M
Appl Physiol Nutr Metab . 2025 Mar; PMID: 40068193
Our previous study revealed a significant anti-atherosclerotic effect of Kgengwe seed powder (KSP) in low-density lipoprotein receptor knockout (LDL-r-KO) mice. The importance of various lipid and protein metabolites, including certain...
2.
Kahnamoui S, Winter T, Lloyd D, Halayko A, Mookherjee N, Aukema H, et al.
J Proteome Res . 2025 Jan; 24(2):672-684. PMID: 39752600
Oxylipins, diverse lipid mediators derived from fatty acids, play key roles in respiratory physiology, but the contribution of lung structural cells to this diverse profile is not well understood. This...
3.
Cayer L, Karakach T, Roberts J, Brooks S, Raju J, Aukema H
Food Chem Toxicol . 2024 Nov; 194:115080. PMID: 39491768
2-Monochloropropane-1,3-diol (2-MCPD) is a food contaminant with demonstrated cardiotoxicity in rats. This adverse effect was previously associated with lower anti-inflammatory docosahexaenoic acid (DHA)-derived cardiac oxylipins in F344 rats. This previous...
4.
Manson A, Sidhu K, Fedorova O, La H, Magaji E, Nguyen L, et al.
J Nutr . 2024 Oct; 154(12):3681-3692. PMID: 39401685
Background: The dietary requirement for α-linolenic acid (ALA) remains unclear, as evidenced by the absence of a Recommended Dietary Allowance (RDA) for this essential fatty acid (FA). In previous studies,...
5.
Cayer L, Buhrke T, Roberts J, Nunnikhoven A, Sommerkorn K, Reinhold A, et al.
Arch Toxicol . 2024 Sep; 98(12):4033-4045. PMID: 39316134
Many foods including edible oils contain 2-monochloropropane-1,3-diol (2-MCPD), a processing-induced chemical contaminant. Cardiotoxic effects have been shown to result from oral 2-MCPD exposure in rodents, but the underlying mechanisms of...
6.
Cayer L, Roberts J, Raju J, Aukema H
Food Chem Toxicol . 2024 Sep; 193:115004. PMID: 39284412
Chloropropanols have been identified as processing-induced food contaminants that occur as by-products of the manufacturing of refined food oils and hydrolyzed vegetable protein. There has been a paucity of research...
7.
Kowatsch M, Winter T, Oyugi J, Kimani J, Lajoie J, Aukema H, et al.
Prostaglandins Other Lipid Mediat . 2024 Jul; 174:106878. PMID: 39084323
Background: 1.5 million new HIV infections occurred in 2021, suggesting new prevention methods are needed. Inflammation increases the risk for HIV acquisition by attracting HIV target cells to the female...
8.
Telles-Langdon S, Arya V, Haasbeek P, Cheung D, Eekhoudt C, Mackic L, et al.
CJC Open . 2024 Jul; 6(7):925-937. PMID: 39026621
Background: Although the current combination of surgery, radiation, and chemotherapy is used in the breast-cancer setting, the administration of the anticancer drugs doxorubicin and trastuzumab is associated with an increased...
9.
Jannas-Vela S, Candia A, Penailillo L, Barrios-Troncoso P, Zapata-Urzua J, Rey-Puente J, et al.
F1000Res . 2024 May; 12:942. PMID: 38778807
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by autoantibody production and synovial membrane damage. It significantly impairs overall function and quality of life. Consumption of omega-3 (n-3) polyunsaturated...
10.
ONeil L, Anaparti V, Winter T, Smolik I, Meng X, Aukema H, et al.
Arthritis Res Ther . 2024 Feb; 26(1):51. PMID: 38360827
Background: Rheumatoid arthritis (RA) is typically preceded by an extended preclinical period where circulating autoantibodies, particularly anti-citrullinated protein antibodies (ACPA), are detectable in the absence of clinical arthritis. Increased dietary...