Harley I Kornblum
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Explore the profile of Harley I Kornblum including associated specialties, affiliations and a list of published articles.
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119
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5870
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Recent Articles
11.
Sohrabi A, Lefebvre A, Harrison M, Condro M, Sanazzaro T, Safarians G, et al.
Cell Rep
. 2023 Sep;
42(10):113175.
PMID: 37756163
The mechanical properties of solid tumors influence tumor cell phenotype and the ability to invade surrounding tissues. Using bioengineered scaffolds to provide a matrix microenvironment for patient-derived glioblastoma (GBM) spheroids,...
12.
Patel K, Yao J, Cho N, Sanvito F, Tessema K, Alvarado A, et al.
Neuro Oncol
. 2023 Aug;
26(1):115-126.
PMID: 37591790
Background: Given the invasive nature of glioblastoma, tumor cells exist beyond the contrast-enhancing (CE) region targeted during treatment. However, areas of non-enhancing (NE) tumors are difficult to visualize and delineate...
13.
He L, Ioannidis A, Arambula E, Hoffman C, Joshi P, Kathiravan A, et al.
bioRxiv
. 2023 Aug;
PMID: 37546917
Glioblastoma is the deadliest adult brain cancer. Under the current standard of care almost all patients succumb to the disease and novel treatments are urgently needed. Dopamine receptor antagonists have...
14.
Ludwig K, Le Belle J, Muthukrishnan S, Sperry J, Condro M, Vlashi E, et al.
Antioxid Redox Signal
. 2023 Jul;
39(13-15):890-903.
PMID: 37470216
The goal of this study was to determine whether nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX)-produced reactive oxygen species (ROS) enhance brain tumor growth of glioblastoma (GBM) under hypoxic conditions...
15.
Muthukrishnan S, Qi H, Wang D, Elahi L, Pham A, Alvarado A, et al.
bioRxiv
. 2023 Jul;
PMID: 37461434
Background: A key feature distinguishing high-grade glioma (HGG) from low-grade glioma (LGG) is the extensive neovascularization and endothelial hyperproliferation. Prior work has shown that tumor endothelial cells (TEC) from HGG...
16.
Bailleul J, Ruan Y, Abdulrahman L, Scott A, Yazal T, Sung D, et al.
Neuro Oncol
. 2023 Jun;
25(11):1989-2000.
PMID: 37279645
Background: Resistance to existing therapies is a significant challenge in improving outcomes for glioblastoma (GBM) patients. Metabolic plasticity has emerged as an important contributor to therapy resistance, including radiation therapy...
17.
Gunn K, Myllykoski M, Cao J, Ahmed M, Huang B, Rouaisnel B, et al.
Cancer Discov
. 2023 Feb;
13(6):1478-1497.
PMID: 36847506
Significance: Mutant IDH is known to induce histone hypermethylation. However, it is not known if this hypermethylation is functionally significant or is a bystander effect of (R)-2HG accumulation in IDH-mutant...
18.
Safarians G, Sohrabi A, Solomon I, Xiao W, Bastola S, Rajput B, et al.
Adv Healthc Mater
. 2023 Jan;
12(14):e2203143.
PMID: 36694362
Increased secretion of hyaluronic acid (HA), a glycosaminoglycan abundant in the brain extracellular matrix (ECM), correlates with worse clinical outcomes for glioblastoma (GBM) patients. GBM cells aggressively invade the brain...
19.
Alvarado A, Kornblum H
Neuron
. 2022 Dec;
110(23):3853-3854.
PMID: 36480937
In this issue of Neuron, Bulstrode et al. demonstrate that glioblastoma slice cultures, unlike neural progenitors, are refractory to Zika virus infection. The anti-infective mechanism is myeloid-lineage cell-secreted interferon beta....
20.
Muthukrishnan S, Kawaguchi R, Nair P, Prasad R, Qin Y, Johnson M, et al.
Nat Commun
. 2022 Oct;
13(1):6202.
PMID: 36261421
Glioma stem cells (GSC) exhibit plasticity in response to environmental and therapeutic stress leading to tumor recurrence, but the underlying mechanisms remain largely unknown. Here, we employ single-cell and whole...