Harihara M Mehendale
Overview
Explore the profile of Harihara M Mehendale including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
58
Citations
845
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Dadhania V, Bhushan B, Apte U, Mehendale H
Dose Response
. 2017 Feb;
15(1):1559325817690287.
PMID: 28210203
Preplacement of compensatory tissue repair (CTR) by exposure to a nonlethal dose of a toxicant protects animals against a lethal dose of another toxicant. Although CTR is known to heteroprotect,...
2.
Dadhania V, Muskhelishvili L, Latendresse J, Mehendale H
Int J Toxicol
. 2016 Jul;
35(6):654-665.
PMID: 27451051
Compensatory tissue repair (CTR) in thioacetamide (TA)-primed rats protects them against acetaminophen (APAP)-induced lethality. This study was aimed at investigating the mechanisms of CTR-mediated heteroprotection in mice. Male Swiss Webster...
3.
Devi S, Palkar P, Mehendale H
Curr Protoc Toxicol
. 2012 Oct;
Chapter 14:Unit14.6.
PMID: 23045139
Many hepatotoxicants like acetaminophen, chloroform, carbon tetrachloride, halothane, and thioacetamide cause hepatotoxicity through covalent binding of their reactive metabolites to proteins. The covalent binding to proteins may lead to dysfunction...
4.
Mehendale H
Trends Pharmacol Sci
. 2012 Mar;
33(4):200-6.
PMID: 22443935
Once initiated, how tissue injury expands after high toxicant doses, even after their complete elimination, is not understood. Free-radical generation was initially proposed to mediate progression of injury. However, mechanisms...
5.
Anand S, Mehendale H
Environ Toxicol Pharmacol
. 2011 Jul;
18(2):149-60.
PMID: 21782744
The objective of the present review is to discuss the importance tissue repair in the mixture risk assessment. Studies have revealed the existence of two stages of toxicity: an inflictive...
6.
Anand S, Murthy S, Mumtaz M, Mehendale H
Environ Toxicol Pharmacol
. 2011 Jul;
18(2):143-8.
PMID: 21782743
The objective of this study was to test whether a binary mixture (BM) of chloroform (CHCl(3)) and thioacetamide (TA) causes a dose-dependent liver injury and an opposing tissue repair. Liver...
7.
Bhave V, Donthamsetty S, Latendresse J, Cunningham M, Mehendale H
Toxicol Appl Pharmacol
. 2011 Feb;
251(3):173-80.
PMID: 21277885
We have previously reported that among the other death proteins, hepatic secretory phospholipase A₂ (sPLA₂) is a leading mediator of progression of liver injury initiated by CCl₄ in rats. The...
8.
Nowicki M, Aleksunes L, Sawant S, Dnyanmote A, Mehendale H, Manautou J
Drug Metab Lett
. 2009 Apr;
2(1):11-7.
PMID: 19356064
Membrane transporters are critical for the uptake as well as elimination of chemicals and by-products of metabolism from the liver and kidneys. Since these proteins are important determinants of chemical...
9.
Mitra M, Donthamsetty S, White B, Mehendale H
Toxicol Appl Pharmacol
. 2008 Aug;
231(3):413-22.
PMID: 18674790
Often, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity....
10.
Donthamsetty S, Bhave V, Mitra M, Latendresse J, Mehendale H
Toxicol Appl Pharmacol
. 2008 May;
230(3):327-37.
PMID: 18501395
The objective was to investigate if the hepatotoxic sensitivity in nonalcoholic steatohepatitic mice to acetaminophen (APAP) is due to downregulation of nuclear receptor PPARalpha via lower cell division and tissue...