Harald Kolmar
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Explore the profile of Harald Kolmar including associated specialties, affiliations and a list of published articles.
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218
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2221
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Recent Articles
1.
Lipinski B, Unmuth L, Arras P, Endruszeit R, Becker S, Rodel J, et al.
Protein Sci
. 2025 Feb;
34(3):e70072.
PMID: 39981925
In this work, we have generated bispecific interleukin (IL)-12 surrogate agonists based on camelid-derived single-domain antibodies (sdAbs) targeting the IL-12 receptor (IL-12R) subunits IL-12Rβ1 and IL-12Rβ2. Following immunization and antibody...
2.
Dombrowsky C, Geyer F, Zakharchuk D, Kolmar H
Mol Ther Oncol
. 2025 Feb;
33(1):200931.
PMID: 39895690
Although a considerable number of disease-related biomolecular interactions occur in the cytosol, therapeutic and diagnostic application of target-specific binding proteins is largely confined to surface-exposed or extracellular targets. Therefore, protein-cargo...
3.
Fournier L, Arras P, Pekar L, Kolmar H, Zielonka S, Toleikis L, et al.
Mol Ther Oncol
. 2025 Jan;
33(1):200917.
PMID: 39811682
In this work, we report the discovery and engineering of allosteric variable domains of the heavy chain (VHHs) derived from camelid immunization targeting NKp30, an activating receptor on natural killer...
4.
Belluati A, Bloch A, Koynov K, Muller Nieva M, Bagherabadi M, Andrieu-Brunsen A, et al.
Adv Biol (Weinh)
. 2024 Dec;
:e2400483.
PMID: 39692631
This study investigates the formation and properties of vesicles produced via biocatalytic Polymerization-Induced Self-Assembly (bioPISA) as artificial cells. Methods for achieving size uniformity, including gentle centrifugation and sucrose gradient centrifugation,...
5.
Lins J, Miloslavina Y, Avrutina O, Theiss F, Hofmann S, Kolmar H, et al.
J Am Chem Soc
. 2024 Dec;
146(51):35175-35184.
PMID: 39662885
Hyperpolarization of small peptides by parahydrogen-induced polarization (PHIP) to increase the sensitivity of nuclear magnetic resonance (NMR) techniques is well established, while its application to larger biopolymers is still a...
6.
Habermann J, Happel D, Bloch A, Shin C, Kolmar H
Biotechnol J
. 2024 Dec;
19(12):e202400432.
PMID: 39655405
The masking of therapeutic antibodies by the installation of a blocking module that can be removed under certain physiological conditions, is becoming increasingly important to improve their safety and toxicity...
7.
Fournier L, Guarnera E, Kolmar H, Becker S
Trends Pharmacol Sci
. 2024 Nov;
PMID: 39562213
Allostery represents a fundamental mechanism in protein regulation, enabling modulation of protein function from sites distal to the active site. While traditionally explored in the context of small molecules, allosteric...
8.
Interleukin-11 receptor is an alternative α-receptor for interleukin-6 and the chimeric cytokine IC7
Weitz H, Ettich J, Rafii P, Wittich C, Schultz L, Frank N, et al.
FEBS J
. 2024 Oct;
292(3):523-536.
PMID: 39473075
The cytokine interleukin 6 (IL-6) signals via the IL-6 α-receptor (IL-6Rα or IL-6R) in complex with the gp130 β-receptor. Cell type restricted expression of the IL-6R limits the action of...
9.
Bitsch P, Dessin C, Bitsch S, Voss J, Becker J, Sharma P, et al.
Chembiochem
. 2024 Oct;
26(2):e202400738.
PMID: 39462215
An enhanced variant of the antimitotic toxin cryptophycin was conjugated to the anti-Her2 monoclonal antibody (mAb) Trastuzumab upon Michael addition. Either antibodies with freed hinge-region cysteines or THIOMAB formats with...
10.
Fournier L, Demir D, Elter D, Pekar L, Kolmar H, Toleikis L, et al.
Biol Chem
. 2024 Sep;
405(11-12):765-775.
PMID: 39344812
In this work, we report the development of a platform for the early selection of non-competitive antibody-fragments against cell surface receptors that do not compete for binding of their natural...