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Hans-Peter Marty

Explore the profile of Hans-Peter Marty including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 5
Citations 68
Followers 0
Related Specialties
Chemistry
Biochemistry
Top 10 Co-Authors
Remy Halm
Philipp Schmid
Roger Wermuth
Daniela Alberati
Emmanuel Pinard
Markus Bender
Edilio Borroni
Dominik Hainzl
Synese Jolidon
Judith Lengyel
Published In
J Med Chem
Bioorg Med Chem
Bioorg Med Chem Lett
Affiliations
Soon will be listed here.
Recent Articles
1.
Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib
Obst-Sander U, Ricci A, Kuhn B, Friess T, Koldewey P, Kuglstatter A, et al.
J Med Chem . 2022 Sep; 65(19):13052-13073. PMID: 36178776
Addressing resistance to third-generation EGFR TKIs such as osimertinib via the EGFR mutation remains a highly unmet need in EGFR-driven non-small-cell lung cancer (NSCLC). Herein, we present the discovery of...
2.
Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors
Pinard E, Alberati D, Bender M, Borroni E, Brom V, Burner S, et al.
Bioorg Med Chem Lett . 2010 Oct; 20(23):6960-5. PMID: 20974532
Benzoylisoindolines were discovered as a novel structural class of GlyT1 inhibitors. SAR studies and subsequent lead optimization efforts focused primarily on addressing hERG liability and on improving in vivo efficacy...
3.
Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia
Pinard E, Alanine A, Alberati D, Bender M, Borroni E, Bourdeaux P, et al.
J Med Chem . 2010 May; 53(12):4603-14. PMID: 20491477
The GlyT1 transporter has emerged as a key novel target for the treatment of schizophrenia. Herein, we report on the optimization of the 2-alkoxy-5-methylsulfonebenzoylpiperazine class of GlyT1 inhibitors to improve...
4.
Novel ketolide antibiotics with a fused five-membered lactone ring--synthesis, physicochemical and antimicrobial properties
Hunziker D, Wyss P, Angehrn P, Mueller A, Marty H, Halm R, et al.
Bioorg Med Chem . 2004 Jun; 12(13):3503-19. PMID: 15186835
In an effort to find novel semisynthetic macrolides with extended antibacterial spectrum and improved activity we prepared a series of compounds based on commercially available clarithromycin, a potent and safe...
5.
Novel dihydrofolate reductase inhibitors. Structure-based versus diversity-based library design and high-throughput synthesis and screening
Wyss P, Gerber P, Hartman P, Hubschwerlen C, Locher H, Marty H, et al.
J Med Chem . 2003 May; 46(12):2304-12. PMID: 12773035
Novel 2,4-diaminopyrimidines bearing N,N-disubstituted aminomethyl residues at the 5-position were designed as dihydrofolate reductase (DHFR) inhibitors. These compounds were obtained by treatment of 1-[(2,4-diamino-5-pyrimidinyl)methyl]pyridinium bromide with secondary amines in a...