Hanns Mohler
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Explore the profile of Hanns Mohler including associated specialties, affiliations and a list of published articles.
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Recent Articles
21.
Zeilhofer H, Mohler H, Di Lio A
Trends Pharmacol Sci
. 2009 Jul;
30(8):397-402.
PMID: 19616317
Gamma-aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the brain where it regulates many physiological functions including sleep, anxiety, reward and memory formation. GABAergic neurons and ionotropic GABA(A)...
22.
Balic E, Rudolph U, Fritschy J, Mohler H, Benke D
J Neurochem
. 2009 May;
110(1):244-54.
PMID: 19457072
GABA(A) receptors are pentameric ligand-gated ion channels that are major mediators of fast inhibitory neurotransmission. Clinically relevant GABA(A) receptor subtypes are assembled from alpha5(1-3, 5), beta1-3 and the gamma2 subunit....
23.
Garner M, Mohler H, Stein D, Mueggler T, Baldwin D
Eur Neuropsychopharmacol
. 2009 Mar;
19(6):381-90.
PMID: 19327970
The development of ethologically based behavioural animal models has clarified the anxiolytic properties of a range of neurotransmitter and neuropeptide receptor agonists and antagonists, with several models predicting efficacy in...
24.
Stendel R, Rodriguez Cetina Biefer H, Dekany G, Kubota H, Munz C, Wang S, et al.
Autophagy
. 2008 Dec;
5(2):194-210.
PMID: 19066471
The antibacterial amino-acid derivative taurolidine (TAU) has been recently shown to exhibit anti-neoplastic activity based on a mechanism, which is still unknown in detail. Cytotoxicity and clonogenic assays were performed...
25.
Benke D, Barberis A, Kopp S, Altmann K, Schubiger M, Vogt K, et al.
Neuropharmacology
. 2008 Jul;
56(1):174-81.
PMID: 18602406
Valerian extracts have been used for centuries to alleviate restlessness and anxiety albeit with unknown mechanism of action in vivo. We now describe a specific binding site on GABA(A) receptors...
26.
Mohler H, Rudolph U, Boison D, Singer P, Feldon J, Yee B
Pharmacol Biochem Behav
. 2008 May;
90(1):58-64.
PMID: 18455219
Adaptive purposeful behaviour depends on appropriate modifications of synaptic connectivity that incorporate an organism's past experience. At least some forms of such synaptic plasticity are believed to be mediated by...
27.
Knabl J, Witschi R, Hosl K, Reinold H, Zeilhofer U, Ahmadi S, et al.
Nature
. 2008 Jan;
451(7176):330-4.
PMID: 18202657
Inflammatory diseases and neuropathic insults are frequently accompanied by severe and debilitating pain, which can become chronic and often unresponsive to conventional analgesic treatment. A loss of synaptic inhibition in...
28.
Singer P, Boison D, Mohler H, Feldon J, Yee B
Behav Neurosci
. 2007 Oct;
121(5):815-25.
PMID: 17907814
Selective deletion of glycine transporter 1 (GlyT1) in forebrain neurons enhances N-methyl-D-aspartate receptor (NMDAR)-dependent neurotransmission and facilitates associative learning. These effects are attributable to increases in extracellular glycine availability in...
29.
Stendel R, Scheurer L, Schlatterer K, Stalder U, Pfirrmann R, Fiss I, et al.
Clin Pharmacokinet
. 2007 May;
46(6):513-24.
PMID: 17518510
Background And Objective: Taurolidine is known to have antimicrobial activity. Furthermore, at lower concentrations, it has been found to exert a selective antineoplastic effect in vitro and in vivo. The...
30.
Earnheart J, Schweizer C, Crestani F, Iwasato T, Itohara S, Mohler H, et al.
J Neurosci
. 2007 Apr;
27(14):3845-54.
PMID: 17409249
Stressful experiences in early life are known risk factors for anxiety and depressive illnesses, and they inhibit hippocampal neurogenesis and the expression of GABA(A) receptors in adulthood. Conversely, deficits in...