Hanns Mohler
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Explore the profile of Hanns Mohler including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Mohler H
Dialogues Clin Neurosci
. 2011 Oct;
4(3):261-9.
PMID: 22034214
Inhibitory interneurons in the brain provide the balance to excitatory signaling. On the basis of brain imaging and human genetics, a deficit in GABAergic inhibition (GABA, γ-aminobuiyric acid) has been...
12.
Mohler H
Neuropharmacology
. 2011 Sep;
62(1):42-53.
PMID: 21889518
In the regulation of behavior, the role of GABA neurons has been extensively studied in the circuit of fear, where GABA interneurons play key parts in the acquisition, storage and...
13.
Dubroqua S, Boison D, Feldon J, Mohler H, Yee B
Neurobiol Learn Mem
. 2011 May;
96(2):218-29.
PMID: 21596148
Behavioural characterisation of transgenic mice has been instrumental in search of therapeutic targets for the modulation of cognitive function. However, little effort has been devoted to phenotypic characterisation across environmental...
14.
Mohler H, Boison D, Singer P, Feldon J, Pauly-Evers M, Yee B
Biochem Pharmacol
. 2011 Feb;
81(9):1065-77.
PMID: 21333635
Schizophrenia is characterized by positive symptoms such as hallucinations, negative symptoms such as blunted affect, and symptoms of cognitive deficiency such as deficits in working memory and selective attention. N-methyl-d-aspartate...
15.
Dubroqua S, Singer P, Boison D, Feldon J, Mohler H, Yee B
Behav Neurosci
. 2010 Nov;
124(6):839-50.
PMID: 21038935
Genetic deletion of glycine transporter 1 (GlyT1) in forebrain neurons gives rise to multiple-procognitive phenotypes, presumably due to enhanced N-methyl-d-aspartate receptor (NMDAR) functions. However, concerns over possible harmful excitotoxic effects...
16.
Mohler H
Neuropharmacology
. 2010 Nov;
60(7-8):1042-9.
PMID: 21035473
Key developments in GABA pharmacology over the last 30 years are reviewed with special reference to the advances pioneered by Erminio Costa. His passion for innovative science, and his quest...
17.
Singer P, Boison D, Mohler H, Feldon J, Yee B
Eur Neuropsychopharmacol
. 2010 Jul;
21(5):401-13.
PMID: 20647165
Inhibition of glycine transporter 1 (GlyT1) augments N-methyl-D-aspartate receptor (NMDAR)-mediated transmission and represents a potential antipsychotic drug target according to the NMDAR hypofunction hypothesis of schizophrenia. Preclinical evaluation of GlyT1...
18.
Kopp S, Baur R, Sigel E, Mohler H, Altmann K
ChemMedChem
. 2010 Mar;
5(5):678-81.
PMID: 20235267
No abstract available.
19.
Mohler H
Biochem Soc Trans
. 2009 Nov;
37(Pt 6):1328-33.
PMID: 19909270
Complex brains have developed specialized mechanisms for the grouping of principal cells into temporal coalitions of local or distant networks: the inhibitory interneuron 'clocking' networks. They consist of GABAergic (where...
20.
Singer P, Boison D, Mohler H, Feldon J, Yee B
Behav Neurosci
. 2009 Oct;
123(5):1012-27.
PMID: 19824767
Local availability of glycine near N-methyl-D-aspartate receptors (NMDARs) is partly regulated by neuronal glycine transporter 1 (GlyT1), which can therefore modulate NMDAR function because binding to the glycine site of...