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Hanns Mohler

Explore the profile of Hanns Mohler including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Majchrzak-Stiller B, Buchholz M, Peters I, Waschestjuk D, Strotmann J, Hohn P, et al.
J Cell Mol Med . 2023 Jun; 27(14):2082-2092. PMID: 37390227
GP-2250, a novel anticancer agent, severely limits the energy metabolism, as demonstrated by the inhibition of hexokinase 2 and glyceraldehyde-3-phosphate dehydrogenase and a decrease of ATP. Rescue experiments with supplementary...
2.
Luscher B, Mohler H
F1000Res . 2019 Jul; 8. PMID: 31275559
The GABAergic deficit hypothesis of depression states that a deficit of GABAergic transmission in defined neural circuits is causal for depression. Conversely, an enhancement of GABA transmission, including that triggered...
3.
Benke D, Mohler H
Neuropharmacology . 2017 Aug; 136(Pt A):46-55. PMID: 28764992
Animal studies of several single-gene disorders demonstrate that reversing the molecular signaling deficits can result in substantial symptomatic improvements in function. Focusing on the ratio of excitation to inhibition as...
4.
Mohler H, Rudolph U
F1000Res . 2017 Feb; 6. PMID: 28232865
Learning and memory are dependent on interactive excitatory and inhibitory mechanisms. In this review, we discuss a mechanism called disinhibition, which is the release of an inhibitory constraint that effectively...
5.
Mohler H
Adv Pharmacol . 2015 Jan; 72:1-36. PMID: 25600365
The study of the psychopharmacology of benzodiazepines continues to provide new insights into diverse brain functions related to vigilance, anxiety, mood, epileptiform activity, schizophrenia, cognitive performance, and autism-related social behavior....
6.
Mohler H, Pfirrmann R, Frei K
Int J Oncol . 2014 Sep; 45(4):1329-36. PMID: 25175943
Targeting the oxygen stress response pathway is considered a promising strategy to exert antineoplastic activity in a broad spectrum of tumor types. Supporting this view, we summarize the mechanism of...
7.
Mohler H
Neurochem Res . 2014 Apr; 39(6):1032-6. PMID: 24715673
By binding to the benzodiazepine site, diazepam binding inhibitor (DBI) is associated with negative allosteric modulation (NAM) of GABAA receptors (Costa and Guidotti in Life Sci 49:325-344, 1991). However, the...
8.
Rudolph U, Mohler H
Annu Rev Pharmacol Toxicol . 2013 Oct; 54:483-507. PMID: 24160694
The γ-aminobutyric acid (GABA) system plays a pivotal role in orchestrating the synchronicity of local networks and the functional coupling of different brain regions. Here we review the impact of...
9.
Mohler H
Biochem Pharmacol . 2012 Aug; 84(8):994-9. PMID: 22898099
The cognitive deficits in Down syndrome (DS) are attributed to an excessive hippocampal inhibition, which obstructs neuronal plasticity and normal learning and memory, a view which is largely based on...
10.
Benke D, Mohler H
Curr Protoc Pharmacol . 2012 Feb; Chapter 1:Unit1.16. PMID: 22294164
This unit describes ligand binding assays for the characterization of the benzodiazepine (BZ) site of GABA(A) receptors in the central nervous system. The Basic Protocol provides a procedure for analyzing...