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Hala Al Adhami

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Articles 8
Citations 230
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Recent Articles
1.
Al Adhami H, Vallet J, Schaal C, Schumacher P, Bardet A, Dumas M, et al.
Nucleic Acids Res . 2023 Feb; 51(7):3130-3149. PMID: 36772830
In mammals, many germline genes are epigenetically repressed to prevent their illegitimate expression in somatic cells. To advance our understanding of the mechanisms restricting the expression of germline genes, we...
2.
Al Adhami H, Bardet A, Dumas M, Cleroux E, Guibert S, Fauque P, et al.
BMC Biol . 2022 Mar; 20(1):70. PMID: 35317801
Background: Cytosine DNA methylation is a heritable epigenetic mark present in most eukaryotic groups. While the patterns and functions of DNA methylation have been extensively studied in mouse and human,...
3.
Dahlet T, Truss M, Frede U, Al Adhami H, Bardet A, Dumas M, et al.
Nat Commun . 2021 Jun; 12(1):3582. PMID: 34117224
In mouse development, long-term silencing by CpG island DNA methylation is specifically targeted to germline genes; however, the molecular mechanisms of this specificity remain unclear. Here, we demonstrate that the...
4.
Bender A, Al Adhami H, Dahlet T, Weber M
Methods Mol Biol . 2020 Sep; 2214:207-220. PMID: 32944912
DNA methylation is extensively reprogrammed during mammalian embryogenesis and germ cell development. Protocols for genome-wide bisulfite sequencing enable the quantification of DNA methylation with high precision and single base-pair resolution;...
5.
Dahlet T, Argueso Lleida A, Al Adhami H, Dumas M, Bender A, Ngondo R, et al.
Nat Commun . 2020 Jun; 11(1):3153. PMID: 32561758
Mouse embryos acquire global DNA methylation of their genome during implantation. However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been studied comprehensively. Here we systematically analyze...
6.
Perrier J, Sellem E, Prezelin A, Gasselin M, Jouneau L, Piumi F, et al.
BMC Genomics . 2018 May; 19(1):404. PMID: 29843609
Background: Spermatozoa have a remarkable epigenome in line with their degree of specialization, their unique nature and different requirements for successful fertilization. Accordingly, perturbations in the establishment of DNA methylation...
7.
Valentino S, Tarrade A, Aioun J, Mourier E, Richard C, Dahirel M, et al.
Part Fibre Toxicol . 2016 Jul; 13(1):39. PMID: 27460165
Background: Airborne pollution is a rising concern in urban areas. Epidemiological studies in humans and animal experiments using rodent models indicate that gestational exposure to airborne pollution, in particular diesel...
8.
Al Adhami H, Evano B, Le Digarcher A, Gueydan C, Dubois E, Parrinello H, et al.
Genome Res . 2015 Jan; 25(3):353-67. PMID: 25614607
Genomic imprinting is an epigenetic mechanism that restrains the expression of ∼ 100 eutherian genes in a parent-of-origin-specific manner. The reason for this selective targeting of genes with seemingly disparate...