Hakan K R Karlsson
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Explore the profile of Hakan K R Karlsson including associated specialties, affiliations and a list of published articles.
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20
Citations
1067
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Recent Articles
1.
Dollet L, Kuefner M, Caria E, Rizo-Roca D, Pendergrast L, Abdelmoez A, et al.
Diabetes
. 2022 Jan;
71(4):624-636.
PMID: 35040927
Dysregulation of skeletal muscle metabolism influences whole-body insulin sensitivity and glucose homeostasis. We hypothesized that type 2 diabetes-associated alterations in the plasma metabolome directly contribute to skeletal muscle immunometabolism and...
2.
Gonzalez-Franquesa A, Stocks B, Borg M, Kuefner M, Dalbram E, Nielsen T, et al.
Am J Physiol Cell Physiol
. 2021 Sep;
321(5):C770-C778.
PMID: 34495765
Skeletal muscle is an endocrine organ secreting exercise-induced factors (exerkines), which play a pivotal role in interorgan cross talk. Using mass spectrometry (MS)-based proteomics, we characterized the secretome and identified...
3.
Borg M, Massart J, de Castro Barbosa T, Archilla-Ortega A, Smith J, Lanner J, et al.
J Cachexia Sarcopenia Muscle
. 2021 Aug;
12(5):1232-1248.
PMID: 34342159
Background: Type 2 diabetes and obesity are often seen concurrently with skeletal muscle wasting, leading to further derangements in function and metabolism. Muscle wasting remains an unmet need for metabolic...
4.
Sjogren R, Rizo-Roca D, Chibalin A, Chorell E, Furrer R, Katayama S, et al.
Diabetologia
. 2021 Jun;
64(9):2077-2091.
PMID: 34131782
Aims/hypothesis: Increased levels of branched-chain amino acids (BCAAs) are associated with type 2 diabetes pathogenesis. However, most metabolomic studies are limited to an analysis of plasma metabolites under fasting conditions,...
5.
Karlsson H, Kasahara A, Ikeda M, Chibalin A, Harada J, Ryden M, et al.
Metabolism
. 2021 Feb;
118:154726.
PMID: 33581131
Background & Aims: The physiological regulation and contribution of the multiple phosphorylation sites of insulin receptor substrate 1 (IRS1) to the pathogenesis of insulin resistance is unknown. Our aims were...
6.
Kulkarni S, Karlsson H, Szekeres F, Chibalin A, Krook A, Zierath J
J Biol Chem
. 2011 Aug;
286(40):34567-74.
PMID: 21873433
The 5'-nucleotidase (NT5) family of enzyme dephosphorylates non-cyclic nucleoside monophosphates to produce nucleosides and inorganic phosphates. We hypothesized that gene silencing of NT5 enzymes to increase the intracellular availability of...
7.
Peck G, Chavez J, Roach W, Budnik B, Lane W, Karlsson H, et al.
J Biol Chem
. 2009 Sep;
284(44):30016-23.
PMID: 19740738
Insulin stimulates the translocation of the glucose transporter GLUT4 from intracellular locations to the plasma membrane in adipose and muscle cells. Prior studies have shown that Akt phosphorylation of the...
8.
Karlsson H, Chibalin A, Koistinen H, Yang J, Koumanov F, Wallberg-Henriksson H, et al.
Diabetes
. 2009 Feb;
58(4):847-54.
PMID: 19188436
Objective: In skeletal muscle, insulin stimulates glucose transport activity three- to fourfold, and a large part of this stimulation is associated with a net translocation of GLUT4 from an intracellular...
9.
Richardson C, Rafiqi F, Karlsson H, Moleleki N, Vandewalle A, Campbell D, et al.
J Cell Sci
. 2008 Feb;
121(Pt 5):675-84.
PMID: 18270262
Mutations increasing WNK1 kinase expression in humans cause the pseudohypoaldosteronism type II hypertension syndrome. This condition is treated effectively by thiazide diuretics, which exert their effects by inhibiting the Na+-Cl(-)...
10.
Karlsson H, Zierath J
Cell Biochem Biophys
. 2007 Aug;
48(2-3):103-13.
PMID: 17709880
Insulin increases glucose uptake and metabolism in skeletal muscle by signal transduction via protein phosphorylation cascades. Insulin action on signal transduction is impaired in skeletal muscle from Type 2 diabetic...