Hailey L Gahlon
Overview
Explore the profile of Hailey L Gahlon including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
236
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Recent Articles
1.
Fontana G, MacArthur M, Rotankova N, Di Filippo M, Beer H, Gahlon H
Sci Rep
. 2024 Jan;
14(1):553.
PMID: 38177205
Cancer-associated fibroblasts (CAFs) are components of the tumor microenvironment and represent appealing therapeutic targets for translational studies. Conventional protein-based biomarkers for CAFs have been reported to be limited in their...
2.
Fontana G, Gahlon H
Methods Mol Biol
. 2023 Feb;
2615:281-292.
PMID: 36807799
Mitochondrial DNA (mtDNA) mutations are found in several human pathologies and are associated with aging. Deletion mutations in mtDNA result in the loss of essential genes for mitochondrial function. Over...
3.
He L, Michailidou F, Gahlon H, Zeng W
Chem Res Toxicol
. 2022 Jun;
35(6):901-915.
PMID: 35666914
Given the worldwide popularity of hair dyeing, there is an urgent need to understand the toxicities and risks associated with exposure to chemicals found in hair dye formulations. Hair dyes...
4.
Molecular beacons with oxidized bases report on substrate specificity of DNA oxoguanine glycosylases
Sun J, Antczak N, Gahlon H, Sturla S
Chem Sci
. 2022 May;
13(15):4295-4302.
PMID: 35509469
DNA glycosylase enzymes recognize and remove structurally distinct modified forms of DNA bases, thereby repairing genomic DNA from chemically induced damage or erasing epigenetic marks. However, these enzymes are often...
5.
Gahlon H
Chimia (Aarau)
. 2020 Nov;
74(11):907-908.
PMID: 33243329
In the late 1860s, DNA was first identified by the Swiss physician and biochemist Friedrich Miescher. Since this time, we have solved its structure, learned how DNA divides in our...
6.
Fontana G, Gahlon H
Nucleic Acids Res
. 2020 Oct;
48(20):11244-11258.
PMID: 33021629
Deletions in mitochondrial DNA (mtDNA) are associated with diverse human pathologies including cancer, aging and mitochondrial disorders. Large-scale deletions span kilobases in length and the loss of these associated genes...
7.
Gahlon H, Sturla S
Methods Mol Biol
. 2019 Apr;
1973:299-311.
PMID: 31016710
Polymerase enzymes catalyze the replication of DNA by incorporating deoxynucleoside monophosphates (dNMPs) into a primer strand in a 5' to 3' direction. Monitoring kinetic aspects of this catalytic process provides...
8.
Raz M, Aloisi C, Gahlon H, Sturla S
Acc Chem Res
. 2019 Apr;
52(5):1391-1399.
PMID: 30964643
Chemical damage to DNA is a key initiator of adverse biological consequences due to disruption of the faithful reading of the genetic code. For example, O-alkylguanine ( O-alkylG) DNA adducts...
9.
Aloisi C, Sturla S, Gahlon H
Chem Commun (Camb)
. 2019 Mar;
55(27):3895-3898.
PMID: 30860216
Detecting DNA adducts in cancer genes is important for understanding cancer etiology. This study reports a strategy to identify the mutagenic DNA adduct O-methylguanine in K-Ras. The strategy involves selective...
10.
Gahlon H, Walker A, Cisneros G, Lamers M, Rueda D
Phys Chem Chem Phys
. 2018 Oct;
20(42):26892-26902.
PMID: 30345999
DNA synthesis, carried out by DNA polymerases, requires balancing speed and accuracy for faithful replication of the genome. High fidelity DNA polymerases contain a 3'-5' exonuclease domain that can remove...