Claudia M N Aloisi
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Explore the profile of Claudia M N Aloisi including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
31
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0
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Recent Articles
1.
Aloisi C, Escher N, Kim H, Geisen S, Fontana G, Yeo J, et al.
DNA Repair (Amst)
. 2022 Jan;
110:103262.
PMID: 35030424
Distinct cellular DNA damage repair pathways maintain the structural integrity of DNA and protect it from the mutagenic effects of genotoxic exposures and processes. The occurrence of O-carboxymethylguanine (O-CMG) has...
2.
Geisen S, Aloisi C, Huber S, Sandell E, Escher N, Sturla S
Chem Res Toxicol
. 2021 Jun;
34(6):1518-1529.
PMID: 34061515
The -alkylguanosine adduct -carboxymethyldeoxyguanosine (-CMdG) has been detected at elevated levels in blood and tissue samples from colorectal cancer patients and from healthy volunteers after consuming red meat. The diazo...
3.
Aloisi C, Sandell E, Sturla S
Chem Res Toxicol
. 2021 Jan;
34(1):12-23.
PMID: 33417435
-carboxymethylguanine (-CMG) is a mutagenic DNA adduct that forms at increased levels when people eat meat. It has been studied as a potential initiating event in colorectal carcinogenesis. It can...
4.
Aloisi C, Nilforoushan A, Ziegler N, Sturla S
J Am Chem Soc
. 2020 Mar;
142(15):6962-6969.
PMID: 32196326
DNA mutations can result from replication errors due to different forms of DNA damage, including low-abundance DNA adducts induced by reactions with electrophiles. The lack of strategies to measure DNA...
5.
Raz M, Aloisi C, Gahlon H, Sturla S
Acc Chem Res
. 2019 Apr;
52(5):1391-1399.
PMID: 30964643
Chemical damage to DNA is a key initiator of adverse biological consequences due to disruption of the faithful reading of the genetic code. For example, O-alkylguanine ( O-alkylG) DNA adducts...
6.
Aloisi C, Sturla S, Gahlon H
Chem Commun (Camb)
. 2019 Mar;
55(27):3895-3898.
PMID: 30860216
Detecting DNA adducts in cancer genes is important for understanding cancer etiology. This study reports a strategy to identify the mutagenic DNA adduct O-methylguanine in K-Ras. The strategy involves selective...
7.
Malvezzi S, Farnung L, Aloisi C, Angelov T, Cramer P, Sturla S
Proc Natl Acad Sci U S A
. 2017 Nov;
114(46):12172-12177.
PMID: 29087308
Several anticancer agents that form DNA adducts in the minor groove interfere with DNA replication and transcription to induce apoptosis. Therapeutic resistance can occur, however, when cells are proficient in...
8.
Otto C, Spivak G, Aloisi C, Menigatti M, Naegeli H, Hanawalt P, et al.
Chem Res Toxicol
. 2017 Jan;
30(3):769-776.
PMID: 28076683
Bioactivation as well as DNA repair affects the susceptibility of cancer cells to the action of DNA-alkylating chemotherapeutic drugs. However, information is limited with regard to the relative contributions of...