Hai Le Thanh Nguyen
Overview
Explore the profile of Hai Le Thanh Nguyen including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
128
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Recent Articles
1.
Trujillo-Paez J, Peng G, Le Thanh Nguyen H, Nakamura M, Umehara Y, Yue H, et al.
J Dermatol Sci
. 2024 Mar;
114(1):13-23.
PMID: 38448341
Background: The aberrant expression of tight junction (TJ) proteins play an important role in several diseases with impaired skin barriers, including atopic dermatitis, psoriasis, and chronic wounds. The evidence provided...
2.
Umehara Y, Trujillo-Paez J, Yue H, Peng G, Le Thanh Nguyen H, Okumura K, et al.
Int J Mol Sci
. 2023 Jun;
24(11).
PMID: 37298299
Atopic dermatitis and psoriasis are prevalent chronic inflammatory skin diseases that are characterized by dysfunctional skin barriers and substantially impact patients' quality of life. Vitamin D3 regulates immune responses and...
3.
Le Thanh Nguyen H, Peng G, Trujillo-Paez J, Yue H, Ikutama R, Takahashi M, et al.
Int J Mol Sci
. 2023 Mar;
24(6).
PMID: 36982275
The antimicrobial peptide derived from insulin-like growth factor-binding protein 5 (AMP-IBP5) exhibits antimicrobial activities and immunomodulatory functions in keratinocytes and fibroblasts. However, its role in regulating skin barrier function remains...
4.
Ikutama R, Peng G, Tsukamoto S, Umehara Y, Trujillo-Paez J, Yue H, et al.
J Invest Dermatol
. 2022 Dec;
143(5):751-761.e7.
PMID: 36455652
Human cathelicidin LL-37 is a multifunctional antimicrobial peptide that exhibits antimicrobial and immunomodulatory activities. LL-37 regulates skin barrier function and was recently reported to activate autophagy in macrophages. Because autophagy...
5.
Umehara Y, Takahashi M, Yue H, Trujillo-Paez J, Peng G, Le Thanh Nguyen H, et al.
Int J Mol Sci
. 2022 Aug;
23(15).
PMID: 35955934
The skin produces a plethora of antimicrobial peptides that not only show antimicrobial activities against pathogens but also exhibit various immunomodulatory functions. Human β-defensins (hBDs) are the most well-characterized skin-derived...
6.
Peng G, Tsukamoto S, Ikutama R, Le Thanh Nguyen H, Umehara Y, Trujillo-Paez J, et al.
J Clin Invest
. 2022 Jul;
132(17).
PMID: 35834333
Human β-defensin-3 (hBD-3) exhibits antimicrobial and immunomodulatory activities; however, its contribution to autophagy regulation remains unclear, and the role of autophagy in the regulation of the epidermal barrier in atopic...
7.
Yue H, Song P, Sutthammikorn N, Umehara Y, Trujillo-Paez J, Le Thanh Nguyen H, et al.
Wound Repair Regen
. 2022 Jan;
30(2):232-244.
PMID: 35092133
Impaired keratinocyte functions are major factors that are responsible for delayed diabetic wound healing. In addition to its antimicrobial activity, the antimicrobial peptide derived from insulin-like growth factor-binding protein 5...
8.
Takahashi M, Umehara Y, Yue H, Trujillo-Paez J, Peng G, Le Thanh Nguyen H, et al.
Front Immunol
. 2021 Oct;
12:712781.
PMID: 34594328
In addition to its antimicrobial activity, the skin-derived antimicrobial peptide human β-defensin-3 (hBD-3) promotes keratinocyte proliferation and migration to initiate the wound healing process; however, its effects on fibroblasts, which...
9.
Umehara Y, Kiatsurayanon C, Trujillo-Paez J, Chieosilapatham P, Peng G, Yue H, et al.
Biomedicines
. 2021 Mar;
9(3).
PMID: 33668714
Itch or pruritus is the hallmark of atopic dermatitis and is defined as an unpleasant sensation that evokes the desire to scratch. It is also believed that itch is a...
10.
Yue H, Umehara Y, Trujillo-Paez J, Peng G, Le Thanh Nguyen H, Chieosilapatham P, et al.
Clin Exp Allergy
. 2021 Jan;
51(3):382-392.
PMID: 33394511
Atopic dermatitis (AD) is a chronic relapsing inflammatory cutaneous disease that is often associated with other atopic symptoms, such as food allergy, allergic rhinitis and asthma, leading to significant morbidity...